Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Alpert Medical School of Brown University, Providence, Rhode Island.
Neurourol Urodyn. 2014 Apr;33(4):414-9. doi: 10.1002/nau.22397. Epub 2013 Mar 13.
To develop a comprehensive conceptual framework representing the most important outcomes for women seeking treatment for pelvic organ prolapse (POP).
Twenty-five women with POP were recruited and participated in four semi-structured focus groups to refine and assess the content validity of a conceptual framework representing patient-important outcomes for POP. Specifically, the focus groups addressed the following three aims: (1) to evaluate the content and appropriateness of domains in our framework; (2) to identify gaps in the framework; and (3) to determine the relative importance of our framework domains from the patient perspective. Sessions were transcribed, coded, and qualitatively and quantitatively analyzed using analytic induction and deductive analysis to identify themes and domains relevant to women with POP.
Our focus groups confirmed the importance of vaginal bulge symptoms (discomfort, bother, and adaptation), and the overarching domains and subdomains of physical (physical function and participation), social (social function, relationships, and sexual function), and mental health (emotional distress, preoccupation, and body image). Patients ranked outcomes in the following order of importance: (1) the resolution of vaginal bulge symptoms, (2) improvement in physical function; (3) improvement in sexual function; (4) improvement in body image perception; and (5) improvement in social function.
We developed a conceptual framework for patient important outcomes of women seeking treatment for POP. This framework can improve the transparency and interpretation of POP study findings from the patient perspective. Vaginal bulge and its associated discomfort are most important for the definition of POP treatment success from the patient perspective.
制定一个全面的概念框架，代表寻求治疗盆腔器官脱垂（POP）的女性最重要的结局。
招募了 25 名患有 POP 的女性，并让她们参加了四个半结构化焦点小组，以完善和评估代表 POP 患者重要结局的概念框架的内容有效性。具体来说，焦点小组的目的是：（1）评估我们框架中的领域的内容和适当性；（2）确定框架中的差距；（3）从患者的角度确定我们框架领域的相对重要性。会议内容被转录、编码，并使用分析归纳法和演绎分析法进行定性和定量分析，以确定与 POP 女性相关的主题和领域。
我们的焦点小组证实了阴道膨出症状（不适、困扰和适应）的重要性，以及身体（身体功能和参与）、社会（社会功能、人际关系和性功能）和心理健康（情绪困扰、担忧和身体形象）的总体领域和子领域的重要性。患者按照以下重要性顺序对结局进行了排名：（1）阴道膨出症状的缓解；（2）身体功能的改善；（3）性功能的改善；（4）身体形象感知的改善；以及（5）社会功能的改善。
我们为寻求治疗 POP 的女性制定了一个患者重要结局的概念框架。该框架可以提高从患者角度解释 POP 研究结果的透明度。从患者的角度来看，阴道膨出及其相关不适对于定义 POP 治疗成功最为重要。
