Department of Plant Biology and Pathology, Rutgers University, New Brunswick, NJ, USA.
Adv Virus Res. 2013;86:149-76. doi: 10.1016/B978-0-12-394315-6.00006-4.
Members of the virus family Narnaviridae contain the simplest genomes of any RNA virus, ranging from 2.3 to 3.6 kb and encoding only a single polypeptide that has an RNA-dependent RNA polymerase domain. The family is subdivided into two genera based on subcellular location: members of the genus Narnavirus have been found in the yeast Saccharomyces cerevisiae and in the oomycete Phytophthora infestans and are confined to the cytosol, while members of the genus Mitovirus have been found only in filamentous fungi and are found in mitochondria. None identified thus far encodes a capsid protein; like several other RNA viruses of lower eukaryotes, their genomes are confined within lipid vesicles. As more family members are discovered, their importance as genetic elements is becoming evident. The unique association of the genus Mitovirus with mitochondria renders them potentially valuable tools to study biology of lower eukaryotes.
Narnaviridae 病毒科的成员包含了最简单的 RNA 病毒基因组，大小在 2.3 到 3.6 kb 之间，只编码一个具有 RNA 依赖性 RNA 聚合酶结构域的单一多肽。该科根据亚细胞定位分为两个属：Narnavirus 属的成员已在酵母酿酒酵母和卵菌致病疫霉中发现，局限于细胞质，而 Mitovirus 属的成员仅在丝状真菌中发现，存在于线粒体中。迄今为止尚未发现任何编码衣壳蛋白的成员; 像其他几种低等真核生物的 RNA 病毒一样，它们的基因组局限于脂囊泡内。随着更多家族成员的发现，它们作为遗传元件的重要性变得越来越明显。Mitovirus 属与线粒体的独特关联使它们成为研究低等真核生物生物学的潜在有价值的工具。
