Thomann U, Meier-Gibbons F, Schipper I
Eye Clinic, Cantonal Hospital, Lucerne, Switzerland.
Br J Ophthalmol. 1995 Apr;79(4):335-8. doi: 10.1136/bjo.79.4.335.
This study was designed to investigate the therapeutic potential of excimer laser for recurrent painful erosions in patients not suited to treatment with penetrating keratoplasty.
Phototherapeutic keratectomy (PTK) with the excimer laser was performed prospectively on a series of 13 eyes of 12 patients with recurrent corneal erosions in connection with bullous keratopathy of varied aetiology. The main complaint of the patients before the treatment was frequent attacks of pain. The patients selected either refused corneal grafting or could not for a variety of reasons expect to profit visually from an operation. The treatment was performed with the MEL 60 Aesculap Meditec excimer laser using either a spot mode (five cases), a scanning mode (three cases), or a combination of both (five cases).
All patients responded well to the treatment, and the pain subsided after a couple of weeks. In five cases (38.5%) a second treatment was necessary because of persistent pain, which was, however, much less than before the initial treatment. In four of these five patients small corneal bullae persisted. The visual performance of the seven patients with visual acuity better than 20/200 ameliorated in two cases and remained unchanged in four cases. One patient lost two Snellen lines after the laser treatment for terminal glaucoma. The mean follow up was 14.1 months (range 1-28 months). No complications were seen so far.
It was concluded that PTK is a very promising and effective outpatient treatment for patients with bullous keratopathy. This therapeutic approach is not thought to have been described before.
本研究旨在探讨准分子激光对不适于穿透性角膜移植术治疗的复发性疼痛性角膜糜烂患者的治疗潜力。
对一系列12例患者的13只眼进行前瞻性研究,这些患者因各种病因的大疱性角膜病变而出现复发性角膜糜烂。治疗前患者的主要诉求是频繁发作的疼痛。所选患者要么拒绝角膜移植,要么因各种原因预计无法从手术中获得视力改善。使用MEL 60蛇牌美迪泰克准分子激光进行治疗,采用光斑模式(5例)、扫描模式(3例)或两者结合(5例)。
所有患者对治疗反应良好,疼痛在几周后消退。5例(38.5%)患者因疼痛持续需要进行第二次治疗,但其疼痛程度比初次治疗前轻得多。这5例患者中有4例角膜小水疱持续存在。7例视力优于20/200的患者中,2例视力改善,4例视力不变。1例患者因终末期青光眼接受激光治疗后视力下降两行。平均随访时间为14.1个月(范围1 - 28个月)。目前未观察到并发症。
得出结论,光治疗性角膜切削术(PTK)对于大疱性角膜病变患者是一种非常有前景且有效的门诊治疗方法。此前认为这种治疗方法尚未被描述过。