First Department of Internal Medicine (Nephrology and Rheumatology), Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
Clin Exp Nephrol. 2013 Oct;17(5):634-637. doi: 10.1007/s10157-013-0787-7. Epub 2013 Mar 16.
It is well known that antineutrophil cytoplasmic antibodies (ANCAs) are pathogenic and have a diagnostic value for ANCA-associated vasculitis. We demonstrated that a rise in myeloperoxidase (MPO)-ANCA titers during remission is often predictive of a future relapse in MPO-ANCA-associated vasculitis. Pathological examination of renal biopsies indicated that not only MPO-ANCAs, but also extracellular MPO, an in situ immune complex composed of MPO and MPO antibodies, may play important roles in the pathogenesis of glomerular capillary injury in MPO-ANCA-associated vasculitis.
众所周知，抗中性粒细胞胞浆抗体（ANCA）是致病性的，对 ANCA 相关性血管炎具有诊断价值。我们证明，在缓解期间髓过氧化物酶（MPO）-ANCA 滴度的升高常常预示着 MPO-ANCA 相关性血管炎的未来复发。肾活检的病理检查表明，不仅 MPO-ANCAs，而且细胞外 MPO，一种由 MPO 和 MPO 抗体组成的原位免疫复合物，可能在 MPO-ANCA 相关性血管炎的肾小球毛细血管损伤发病机制中发挥重要作用。
