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潘顿-瓦伦丁杀白细胞素金黄色葡萄球菌在一名小男孩身上引发致命性坏死性肺炎。

Panton-Valentine leukocidin Staphylococcus causing fatal necrotising pneumonia in a young boy.

作者信息

Haider Shahzad, Wright David

机构信息

Department of Paediatrics, Macclesfield District General Hospital, Macclesfield, UK.

出版信息

BMJ Case Rep. 2013 Mar 14;2013:bcr2012007655. doi: 10.1136/bcr-2012-007655.

DOI:10.1136/bcr-2012-007655
PMID:23505079
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3618712/
Abstract

Panton-Valentine leukocidin (PVL) toxin producing strains of Staphylococcus aureus are known to cause skin and soft tissue infection. They can also cause necrotising pneumonia in otherwise healthy individuals. Here we report a case of severe, necrotising, haemorrhagic pneumonia in a 12-year-old boy who presented with a four-day history of a sore throat and fever. During his admission he deteriorated and needed full ventilatory support but despite all efforts he died. Postmortem examination lung swabs confirmed the presence of PVL-associated S aureus. There is a need to improve awareness of this disease among medical practitioners as early diagnosis and appropriate management can save lives.

摘要

已知产杀白细胞素(PVL)的金黄色葡萄球菌菌株可引起皮肤和软组织感染。它们也可在原本健康的个体中导致坏死性肺炎。在此,我们报告一例12岁男孩患严重、坏死性、出血性肺炎的病例,该男孩有四天的咽痛和发热病史。住院期间病情恶化,需要完全通气支持,但尽管全力救治仍死亡。尸检肺拭子证实存在与PVL相关的金黄色葡萄球菌。有必要提高医生对这种疾病的认识,因为早期诊断和适当治疗可挽救生命。

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2
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本文引用的文献

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Sudden death caused by Staphylococcus aureus carrying Panton-Valentine leukocidin gene in a young girl.一名携带杀白细胞素基因的金黄色葡萄球菌导致的年轻女孩猝死。
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Severe invasive Panton-Valentine Leucocidin positive Staphylococcus aureus infections in children in London, UK.英国伦敦儿童中严重侵袭性泛耐药性白细胞毒素阳性金黄色葡萄球菌感染
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Diagnosis and treatment of Panton-Valentine leukocidin (PVL)-associated staphylococcal pneumonia.杀白细胞素(PVL)相关葡萄球菌肺炎的诊断与治疗
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Factors predicting mortality in necrotizing community-acquired pneumonia caused by Staphylococcus aureus containing Panton-Valentine leukocidin.预测由含杀白细胞素的金黄色葡萄球菌引起的坏死性社区获得性肺炎死亡率的因素。
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Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia.金黄色葡萄球菌杀白细胞素可导致坏死性肺炎。
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