乳铁蛋白：抗菌活性与治疗潜力。

Lactoferrin: Antimicrobial activity and therapeutic potential.

作者信息

Embleton Nicholas D, Berrington Janet E, McGuire William, Stewart Chris J, Cummings Stephen P

机构信息

Newcastle Neonatal Service, Newcastle upon Tyne Hospitals NHS Foundation Trust, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK; Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.

出版信息

Semin Fetal Neonatal Med. 2013 Jun;18(3):143-149. doi: 10.1016/j.siny.2013.02.001. Epub 2013 Mar 16.

DOI:10.1016/j.siny.2013.02.001

PMID:23507150

Abstract

Lactoferrin is a highly conserved protein from an evolutionary perspective, with a wide range of roles related to protection from infection and promotion of nutritional status. Infection, malnutrition and intestinal pathologies are key inter-related problems, represent important threats to survival and are associated with adverse long-term health outcomes after preterm birth. Lactoferrin is available as a commercial extract from bovine milk and offers potential as a therapeutic intervention for preterm infants modulating infections and intestinal pathologies. In this review we explore the structure, direct antimicrobial effects, modification of host immune function and gastrointestinal effects of lactoferrin. Current trial data are reviewed, and research priorities and challenges identified and discussed.

摘要

从进化的角度来看，乳铁蛋白是一种高度保守的蛋白质，具有多种与预防感染和促进营养状况相关的作用。感染、营养不良和肠道疾病是关键的相互关联问题，对生存构成重要威胁，并且与早产后期的不良长期健康后果相关。乳铁蛋白可以从牛乳中作为商业提取物获得，具有作为调节感染和肠道疾病的早产儿治疗干预措施的潜力。在本综述中，我们探讨了乳铁蛋白的结构、直接抗菌作用、对宿主免疫功能的调节以及对胃肠道的影响。我们回顾了当前的试验数据，并确定和讨论了研究重点及挑战。