Stanford Molecular Imaging Program (MIPS), Department of Radiology, Stanford University, Stanford, CA 94305-5484, USA.
Nanoscale. 2013 Apr 21;5(8):3253-6. doi: 10.1039/c3nr00335c. Epub 2013 Mar 19.
We report a simple, efficient synthesis of novel (18)F-labeled imaging agents based on YF3 nanoparticles. Targeting ligands and antitumor drug molecules can be introduced onto the YF3 nanoparticles in a one-pot synthesis. The (18)F-labeling reaction proceeds in aqueous solutions at room temperature with excellent radiolabeling yields (>80%) in a very short time (5-10 min). (18)F-labeled YF3 nanoparticles displayed high stability in mouse and human serum, and their application for mapping lymph nodes in live rats after local injection has also been demonstrated.
我们报告了一种基于 YF3 纳米粒子的新型（18）F 标记成像剂的简单、高效合成方法。靶向配体和抗肿瘤药物分子可以在一锅合成中引入到 YF3 纳米粒子上。（18）F 标记反应在室温下的水溶液中进行，具有非常短的时间（5-10 分钟）内的优异放射性标记产率（>80%）。（18）F 标记的 YF3 纳米粒子在小鼠和人血清中表现出高稳定性，并且已经证明它们在局部注射后用于活体大鼠淋巴结成像的应用。
