合成配体功能化的水溶性[18F]YF3 纳米颗粒，用于 PET 成像。
Synthesis of ligand-functionalized water-soluble [18F]YF3 nanoparticles for PET imaging.
机构信息
Stanford Molecular Imaging Program (MIPS), Department of Radiology, Stanford University, Stanford, CA 94305-5484, USA.
出版信息
Nanoscale. 2013 Apr 21;5(8):3253-6. doi: 10.1039/c3nr00335c. Epub 2013 Mar 19.
Abstract
We report a simple, efficient synthesis of novel (18)F-labeled imaging agents based on YF3 nanoparticles. Targeting ligands and antitumor drug molecules can be introduced onto the YF3 nanoparticles in a one-pot synthesis. The (18)F-labeling reaction proceeds in aqueous solutions at room temperature with excellent radiolabeling yields (>80%) in a very short time (5-10 min). (18)F-labeled YF3 nanoparticles displayed high stability in mouse and human serum, and their application for mapping lymph nodes in live rats after local injection has also been demonstrated.
摘要
我们报告了一种基于 YF3 纳米粒子的新型（18）F 标记成像剂的简单、高效合成方法。靶向配体和抗肿瘤药物分子可以在一锅合成中引入到 YF3 纳米粒子上。（18）F 标记反应在室温下的水溶液中进行，具有非常短的时间（5-10 分钟）内的优异放射性标记产率（>80%）。（18）F 标记的 YF3 纳米粒子在小鼠和人血清中表现出高稳定性，并且已经证明它们在局部注射后用于活体大鼠淋巴结成像的应用。
相似文献
1
Synthesis of ligand-functionalized water-soluble [18F]YF3 nanoparticles for PET imaging.合成配体功能化的水溶性[18F]YF3 纳米颗粒，用于 PET 成像。
Nanoscale. 2013 Apr 21;5(8):3253-6. doi: 10.1039/c3nr00335c. Epub 2013 Mar 19.
2
Fluorine-18 labeled rare-earth nanoparticles for positron emission tomography (PET) imaging of sentinel lymph node.氟-18 标记的稀土纳米颗粒用于前哨淋巴结的正电子发射断层扫描（PET）成像。
Biomaterials. 2011 Apr;32(11):2999-3007. doi: 10.1016/j.biomaterials.2011.01.011. Epub 2011 Feb 3.
3
AlF-Labeling Of Heat-Sensitive Biomolecules for Positron Emission Tomography Imaging.用于正电子发射断层成像的热敏感生物分子的铝氟标记
Theranostics. 2017 Jul 14;7(11):2924-2939. doi: 10.7150/thno.20094. eCollection 2017.
4
Rapid one-step F-radiolabeling of biomolecules in aqueous media by organophosphine fluoride acceptors.通过有机膦氟化物受体在水相介质中快速一步 F-放射性标记生物分子。
Nat Commun. 2019 Mar 1;10(1):989. doi: 10.1038/s41467-019-08953-0.
5
Cu(I)-mediated (18)F-trifluoromethylation of arenes: rapid synthesis of (18)F-labeled trifluoromethyl arenes.铜（I）介导的芳烃（18）F-三氟甲基化反应：（18）F标记的三氟甲基芳烃的快速合成
Chem Commun (Camb). 2014 Jun 7;50(45):6056-9. doi: 10.1039/c4cc01641f. Epub 2014 Apr 28.
6
One-step ¹⁸F-labeling of carbohydrate-conjugated octreotate-derivatives containing a silicon-fluoride-acceptor (SiFA): in vitro and in vivo evaluation as tumor imaging agents for positron emission tomography (PET).一步法¹⁸F 标记含硅-氟受体（SiFA）的碳水化合物偶联奥曲肽衍生物：作为正电子发射断层扫描（PET）肿瘤成像剂的体外和体内评价。
Bioconjug Chem. 2010 Dec 15;21(12):2289-96. doi: 10.1021/bc100316c. Epub 2010 Nov 17.
7
Fluorine-18-labeled Gd3+/Yb3+/Er3+ co-doped NaYF4 nanophosphors for multimodality PET/MR/UCL imaging.氟-18 标记的 Gd3+/Yb3+/Er3+共掺杂 NaYF4 纳米荧光粉用于多模态 PET/MR/UCL 成像。
Biomaterials. 2011 Feb;32(4):1148-56. doi: 10.1016/j.biomaterials.2010.09.071. Epub 2010 Oct 20.
8
Direct fluorine-18 labeling of heat-sensitive biomolecules for positron emission tomography imaging using the AlF-RESCA method.采用 AlF-RESCA 方法对热敏生物分子进行直接 18F 标记用于正电子发射断层成像。
Nat Protoc. 2018 Oct;13(10):2330-2347. doi: 10.1038/s41596-018-0040-7.
9
New strategies for rapid (18)F-radiolabeling of biomolecules for radionuclide-based in vivo imaging.用于基于放射性核素的体内成像的生物分子快速（18）F放射性标记的新策略。
Bioconjug Chem. 2015 Jun 17;26(6):1000-3. doi: 10.1021/acs.bioconjchem.5b00180. Epub 2015 May 19.
10
Folate-PEG-NOTA-AlF: A New Folate Based Radiotracer for PET Imaging of Folate Receptor-Positive Tumors.叶酸-PEG-NOTA-AlF：一种新型叶酸基放射性示踪剂，用于正电子发射断层扫描成像叶酸受体阳性肿瘤。
Mol Pharm. 2017 Dec 4;14(12):4353-4361. doi: 10.1021/acs.molpharmaceut.7b00415. Epub 2017 Nov 1.
引用本文的文献
1
[F]-Radiolabelled Nanoplatforms: A Critical Review of Their Intrinsic Characteristics, Radiolabelling Methods, and Purification Techniques.[F]-放射性标记纳米平台：其固有特性、放射性标记方法和纯化技术的批判性综述。
Molecules. 2024 Mar 29;29(7):1537. doi: 10.3390/molecules29071537.
2
Methods for Radiolabelling Nanoparticles: PET Use (Part 2).放射性标记纳米粒子的方法：正电子发射断层扫描的应用（第 2 部分）。
Biomolecules. 2022 Oct 20;12(10):1517. doi: 10.3390/biom12101517.
3
Real-Space Image of Charged Patches in Tunable-Size Nanocrystals.可调尺寸纳米晶体中带电斑块的实空间图像。
Materials (Basel). 2022 Feb 15;15(4):1455. doi: 10.3390/ma15041455.
4
Tunable Self-Assembly of YF Nanoparticles by Citrate-Mediated Ionic Bridges.通过柠檬酸盐介导的离子桥实现 YF 纳米粒子的可调自组装。
J Am Chem Soc. 2018 Feb 14;140(6):2127-2134. doi: 10.1021/jacs.7b09821. Epub 2018 Jan 30.
5
Quantification of endocytosis using a folate functionalized silica hollow nanoshell platform.使用叶酸功能化二氧化硅中空纳米壳平台进行内吞作用的定量分析。
J Biomed Opt. 2015 Aug;20(8):88003. doi: 10.1117/1.JBO.20.8.088003.
本文引用的文献
1
Self-luminescing BRET-FRET near-infrared dots for in vivo lymph-node mapping and tumour imaging.自发光 BRET-FRET 近红外点用于体内淋巴结成像和肿瘤成像。
Nat Commun. 2012;3:1193. doi: 10.1038/ncomms2197.
2
Near-infrared emitting polymer nanogels for efficient sentinel lymph node mapping.用于高效前哨淋巴结定位的近红外发射聚合物纳米凝胶。
ACS Nano. 2012 Sep 25;6(9):7820-31. doi: 10.1021/nn301949y. Epub 2012 Aug 8.
3
Upconversion nanophosphors for small-animal imaging.上转换纳米荧光粉在小动物成像中的应用。
Chem Soc Rev. 2012 Feb 7;41(3):1323-49. doi: 10.1039/c1cs15187h. Epub 2011 Oct 19.
4
Spectroscopic properties and upconversion in Pr3+:YF3 nanoparticles.掺镨氟化钇纳米颗粒的光谱性质和上转换。
Phys Chem Chem Phys. 2011 Oct 21;13(39):17453-60. doi: 10.1039/c1cp20725c. Epub 2011 Sep 2.
5
MRI of tumor-associated macrophages with clinically applicable iron oxide nanoparticles.临床应用氧化铁纳米颗粒对肿瘤相关巨噬细胞进行 MRI 成像。
Clin Cancer Res. 2011 Sep 1;17(17):5695-704. doi: 10.1158/1078-0432.CCR-10-3420. Epub 2011 Jul 26.
6
18F-Labeled magnetic-upconversion nanophosphors via rare-Earth cation-assisted ligand assembly.18F 标记的磁性上转换纳米荧光粉通过稀土阳离子辅助配体组装。
ACS Nano. 2011 Apr 26;5(4):3146-57. doi: 10.1021/nn200298y. Epub 2011 Mar 16.
7
Fluorine-18 labeled rare-earth nanoparticles for positron emission tomography (PET) imaging of sentinel lymph node.氟-18 标记的稀土纳米颗粒用于前哨淋巴结的正电子发射断层扫描（PET）成像。
Biomaterials. 2011 Apr;32(11):2999-3007. doi: 10.1016/j.biomaterials.2011.01.011. Epub 2011 Feb 3.
8
Tuning from blue to magenta the up-converted emissions of YF3:Tm3+/Yb3+ nanocrystals.调谐上转换 YF3:Tm3+/Yb3+ 纳米晶体的发射从蓝色到品红色。
Nanoscale. 2011 Mar;3(3):1046-52. doi: 10.1039/c0nr00676a. Epub 2010 Dec 13.
9
Fluorine-18-labeled Gd3+/Yb3+/Er3+ co-doped NaYF4 nanophosphors for multimodality PET/MR/UCL imaging.氟-18 标记的 Gd3+/Yb3+/Er3+共掺杂 NaYF4 纳米荧光粉用于多模态 PET/MR/UCL 成像。
Biomaterials. 2011 Feb;32(4):1148-56. doi: 10.1016/j.biomaterials.2010.09.071. Epub 2010 Oct 20.
10
The synthesis of rare earth fluoride based nanoparticles.基于氟化物的稀土纳米粒子的合成。
Nanoscale. 2009 Nov;1(2):214-24. doi: 10.1039/b9nr00089e. Epub 2009 Aug 13.
Zotero 插件