First Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, PR China, and the Medical College of Nankai University, Tianjin, PR China.
Am J Clin Nutr. 2013 May;97(5):926-35. doi: 10.3945/ajcn.112.049833. Epub 2013 Mar 20.
The effects of fish oil on heart rate variability in humans remain unclear.
A meta-analysis of randomized controlled trials was performed to investigate the influence of fish oil on heart rate variability.
Human intervention studies were identified by systematic search of PubMed, Embase, The Cochrane Library, and references of related reviews and studies. A random-effects model was applied to estimate the pooled results.
Fifteen studies were included. Results of the meta-analysis showed that the SD of normal-to-normal interval [standardized mean difference (SMD) = 0.10, P = 0.35] and square of successive differences (SMD = 0.05, P = 0.35), 2 of the time-domain parameters of heart rate variability, were not significantly influenced by fish-oil supplementation. For the frequency-domain parameters, the high-frequency power (HF), a surrogate of vagal function, was significantly increased by fish-oil supplementation (SMD = 0.30, P = 0.005), the low-frequency power (LF) was not significantly affected (SMD = 0.03, P = 0.79), and the ratio of LF to HF (LF/HF) showed a trend of reduction (SMD = -0.22, P = 0.08). The trend for a treatment effect on LF/HF became significant at P = 0.01 when the 2 studies with a dose <1000 mg/d were omitted. Subgroup analyses according to predefined study characteristics showed no significant results.
Short-term fish-oil supplementation may favorably influence the frequency domain of heart rate variability, as indicated by an enhanced vagal tone, which may be an important mechanism underlying the antiarrhythmic and other clinical effects of fish oil.
鱼油对人心率变异性的影响仍不清楚。
通过系统检索 PubMed、Embase、The Cochrane Library 以及相关综述和研究的参考文献，进行荟萃分析，以调查鱼油对心率变异性的影响。
通过系统检索PubMed、Embase、The Cochrane Library 以及相关综述和研究的参考文献，确定人类干预研究。应用随机效应模型来估计汇总结果。
纳入了 15 项研究。荟萃分析结果表明，正常-正常间期的标准差（标准化均数差 [SMD] = 0.10，P = 0.35）和连续差值的平方（SMD = 0.05，P = 0.35），即心率变异性的 2 个时域参数并未受到鱼油补充的显著影响。对于频域参数，高频功率（HF），迷走神经功能的替代指标，显著增加了鱼油的补充（SMD = 0.30，P = 0.005），低频功率（LF）未受显著影响（SMD = 0.03，P = 0.79），LF 与 HF 的比值（LF/HF）呈降低趋势（SMD = -0.22，P = 0.08）。当排除剂量 <1000 mg/d 的 2 项研究时，LF/HF 的治疗效果呈显著趋势（P = 0.01）。根据预先设定的研究特征进行的亚组分析没有显示出显著的结果。
短期鱼油补充可能会对心率变异性的频域产生有利影响，这表明迷走神经张力增强，这可能是鱼油抗心律失常和其他临床作用的重要机制。
