Musazadeh Vali, Kavyani Zeynab, Naghshbandi Behnaz, Dehghan Parvin, Vajdi Mahdi
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Community Nutrition, School of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Front Nutr. 2022 Aug 18;9:985451. doi: 10.3389/fnut.2022.985451. eCollection 2022.
Several meta-analyses have revealed that n-3 PUFAs can lower blood pressure, but the findings are conflicting. In this regard, the present umbrella meta-analysis aimed was performed to clarify whether n-3 PUFAs have effects on blood pressure. PubMed, Scopus, Embase, Web of Science, and Google Scholar were used as international databases from inception to May 2022. To examine the effects of n-3 PUFA supplementation on blood pressure, a random-effects model was applied. The leave-one-out method was performed for the sensitivity analysis. The pooled estimate of 10 meta-analyses with 20 effect sizes revealed significant reductions in both systolic (ES = -1.19 mmHg; 95% CI: -1.76, -0.62, < 0.001) and diastolic blood pressure (ES = -0.91 mmHg, 95% CI: -1.35, -0.47; < 0.001) following n-3 PUFAs supplementation. In studies with a sample size of ≤ 400 participants and a mean age over 45, SBP and DBP were found to be substantially reduced. Overall, this umbrella meta-analysis indicates that n-3 PUFAs supplementation might play a role in improving DBP and SBP.
多项荟萃分析表明，n-3多不饱和脂肪酸（PUFAs）可降低血压，但研究结果相互矛盾。在此方面，开展了本项汇总荟萃分析，旨在阐明n-3 PUFAs是否对血压有影响。从数据库建立至2022年5月，将PubMed、Scopus、Embase、Web of Science和谷歌学术作为国际数据库。为检验补充n-3 PUFA对血压的影响，应用了随机效应模型。采用留一法进行敏感性分析。对10项荟萃分析、20个效应量的汇总估计显示，补充n-3 PUFAs后，收缩压（效应量= -1.19 mmHg；95%置信区间：-1.76，-0.62；P<0.001）和舒张压（效应量= -0.91 mmHg，95%置信区间：-1.35，-0.47；P<0.001）均显著降低。在样本量≤400名参与者且平均年龄超过45岁的研究中，收缩压和舒张压大幅降低。总体而言，本项汇总荟萃分析表明，补充n-3 PUFAs可能在改善舒张压和收缩压方面发挥作用。
