Department of Laboratory Medicine, the 82nd Hospital of the People's Liberation Army, Huaian, 223001, China.
Cell Biochem Biophys. 2013 Nov;67(2):657-68. doi: 10.1007/s12013-013-9554-3.
Esophageal squamous cell carcinoma (ESCC) is the leading malignancy in Huaian, China. Recently, emerging studies have suggested that an aberrant microRNA (miRNA) expression signature exists in ESCC. However, there is discordant information available on specific miRNA expression in patients from different regions. In this study, we identified 12 miRNAs that are differentially expressed in patients with ESCC from Huaian, China. Among these miRNAs that displayed unique miRNA expression signatures, miR-1, miR-29c, miR-100, miR-133a, miR-133b, miR-143, miR-145, and miR-195 were downregulated, and miR-7, miR-21, miR-223, and miR-1246 were upregulated in cancerous tissue compared with the adjacent normal tissue. Bioinformatics analyses identified the major biological processes and signaling pathways that are targeted by these differentially expressed miRNAs. Accordingly, miR-29c, miR-100, miR-133a, and miR-133b were found to be involved in invasion and metastasis of ESCC, and miR-7 and miR-21 were found to be related to the differentiation of ESCC. Thus, our data present new evidence for the important roles of miRNAs in ESCC.
食管鳞状细胞癌（ESCC）是中国淮安的主要恶性肿瘤。最近的研究表明，ESCC 存在异常的微小 RNA（miRNA）表达特征。然而，不同地区患者特定 miRNA 表达的具体信息存在不一致。在这项研究中，我们鉴定了 12 个在中国淮安 ESCC 患者中差异表达的 miRNA。在这些显示独特 miRNA 表达特征的 miRNA 中，miR-1、miR-29c、miR-100、miR-133a、miR-133b、miR-143、miR-145 和 miR-195 在癌组织中下调，而 miR-7、miR-21、miR-223 和 miR-1246 在癌组织中上调。生物信息学分析鉴定了这些差异表达 miRNA 靶向的主要生物学过程和信号通路。因此，miR-29c、miR-100、miR-133a 和 miR-133b 被发现参与 ESCC 的侵袭和转移，而 miR-7 和 miR-21 被发现与 ESCC 的分化有关。因此，我们的数据为 miRNA 在 ESCC 中的重要作用提供了新的证据。
