Cohen J C, Berger G M
Research Institute for Nutritional Diseases of the South African Medical Research Council, Cape Town.
J Lipid Res. 1990 Apr;31(4):597-602.
To determine whether the metabolism of diet-derived triglycerides (TG) is acutely regulated by the consumption of insulinogenic carbohydrates, we measured the effects of glucose ingestion on oral and intravenous fat tolerance, and on serum triglyceride concentrations obtained during duodenal fat perfusion. Postprandial lipemia was diminished by the ingestion of 50 g (148 +/- 121 mg.dl-1 x 7 h-1 vs 192 +/- 124 mg.dl-1 x 7 h-1, P less than 0.05) and 100 g (104 +/- 106 mg.dl-1 x 7 h-1 vs 171 +/- 104 mg.dl-1 x 7 h-1, P less than 0.05) glucose. Peak postprandial TG concentrations occurred later after meals containing glucose and fat than after meals containing fat alone. This effect could be reproduced when an iso-osmotic quantity of urea was substituted for glucose in the test meal. Starch ingestion had no discernible effect on postprandial lipemia. Intravenous fat tolerance was similar before (4.9 +/- 1.2%.min-1) and 2 h (4.4 +/- 1.3%.min-1) and 4 h (4.8 +/- 1.5%.min-1) after 50 g glucose ingestion. During duodenal fat perfusion, glucose ingestion caused a progressive decrease in plasma triglyceride concentrations. These data suggest that glucose ingestion diminishes postprandial lipemia in a dose-dependent manner, but that this effect is not due to increased clearance of triglyceride from the circulation. The hypotriglyceridemic effects of glucose appear to reflect delayed gastric emptying and decreased hepatic secretion of triglyceride.
为了确定饮食来源的甘油三酯（TG）代谢是否受到胰岛素生成性碳水化合物摄入的急性调节，我们测量了葡萄糖摄入对口服和静脉脂肪耐量以及十二指肠脂肪灌注期间血清甘油三酯浓度的影响。摄入50克（148±121毫克·分升⁻¹×7小时⁻¹ 对比 192±124毫克·分升⁻¹×7小时⁻¹，P＜0.05）和100克（104±106毫克·分升⁻¹×7小时⁻¹ 对比 171±104毫克·分升⁻¹×7小时⁻¹，P＜0.05）葡萄糖后，餐后血脂血症减轻。含葡萄糖和脂肪的餐后甘油三酯峰值浓度出现的时间比仅含脂肪的餐后更晚。当在测试餐中用等渗量的尿素替代葡萄糖时，这种效应可以重现。摄入淀粉对餐后血脂血症没有明显影响。摄入50克葡萄糖前（4.9±1.2%·分钟⁻¹）、2小时（4.4±1.3%·分钟⁻¹）和4小时（4.8±1.5%·分钟⁻¹）的静脉脂肪耐量相似。在十二指肠脂肪灌注期间，摄入葡萄糖导致血浆甘油三酯浓度逐渐降低。这些数据表明，摄入葡萄糖以剂量依赖的方式减轻餐后血脂血症，但这种效应并非由于循环中甘油三酯清除增加所致。葡萄糖的降甘油三酯作用似乎反映了胃排空延迟和肝脏甘油三酯分泌减少。
