Casanova M F, Sanders R D, Goldberg T E, Bigelow L B, Christison G, Torrey E F, Weinberger D R
Clinical Brain Disorders Branch, National Institute of Mental Health, Washington, DC 20032.
J Neurol Neurosurg Psychiatry. 1990 May;53(5):416-21. doi: 10.1136/jnnp.53.5.416.
The corpus callosum (CC) has been the focus of several morphometric studies of patients with schizophrenia, but the results of these studies have been contradictory. In an attempt to improve the reliability of morphometric measurements of the corpus callosum, a computerised image analysis system was used to measure the shape, area, thickness and length of the CC on magnetic resonance imaging (MRI) in 12 pairs of monozygotic twins discordant for schizophrenia (SC). No differences in CC area (anterior, middle, posterior thirds and total), length or vertical thickness of the CC body (at three levels) were demonstrated by t test comparisons of the affected SC and unaffected twins. Statistical analysis of a Fourier expansion series suggested differences in shape between normal and SC cotwins in the second harmonic of the anterior and middle segments and effects of gender on posterior CC shape. These results fail to replicate previous findings of altered length, thickness and area in the schizophrenic CC, but implicate disease-related shape differences in the anterior and middle segment of the corpus callosum and gender-related differences in splenium shape. The disease-related shape distortion suggest ventriculomegaly rather than an intrinsic abnormality of the corpus callosum.
胼胝体（CC）一直是精神分裂症患者多项形态计量学研究的重点，但这些研究结果相互矛盾。为提高胼胝体形态计量测量的可靠性，采用计算机图像分析系统对12对患精神分裂症（SC）的单卵双胞胎中患病和未患病的双胞胎进行磁共振成像（MRI）检查，测量胼胝体的形状、面积、厚度和长度。通过对患病的SC双胞胎和未患病双胞胎进行t检验比较，未发现胼胝体面积（前三分之一、中间三分之一、后三分之一及总面积）、长度或胼胝体体部垂直厚度（三个层面）存在差异。对傅里叶展开级数的统计分析表明，正常双胞胎和患精神分裂症双胞胎在前段和中段的二次谐波形状存在差异，且性别对胼胝体后段形状有影响。这些结果未能重复先前关于精神分裂症患者胼胝体长度、厚度和面积改变的研究结果，但表明胼胝体前段和中段存在与疾病相关的形状差异，以及压部形状存在与性别相关的差异。与疾病相关的形状畸变提示脑室扩大而非胼胝体本身异常。
