KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Ullevaal Hospital, Oslo, Norway.
Bipolar Disord. 2013 May;15(3):272-83. doi: 10.1111/bdi.12061. Epub 2013 Mar 25.
To examine which subgroups of DSM-IV bipolar disorder (BD) [BD type I (BD-I) or BD type II (BD-II), and subgroups based on history of psychosis, presenting polarity, and age at onset] differentiate best regarding neurocognitive measures.
A total of 199 patients with BD were characterized by clinical and neurocognitive features. The distribution of subgroups in this sample was: BD-I, 64% and BD-II, 36%; 60% had a history of psychosis; 57% had depression as the presenting polarity; 61% had an early onset of BD, 25% had a mid onset, and 14% had a late onset. We used multivariate regression analyses to assess relationships between neurocognitive variables and clinical subgroups.
Both BD-I diagnosis and elevated presenting polarity were related to impairments in verbal memory, with elevated presenting polarity explaining more of the variance in this cognitive domain (22.5%). History of psychosis and BD-I diagnosis were both related to impairment in semantic fluency, with history of psychosis explaining more of the variance (11.6%).
Poor performance in verbal memory appears to be associated with an elevated presenting polarity, and poor performance in semantic fluency appears to be associated with a lifetime history of psychosis.
探讨 DSM-IV 双相障碍（BD）[BD 型 I（BD-I）或 BD 型 II（BD-II），以及基于精神病病史、发病时极性和发病年龄的亚组]在神经认知测量方面的最佳区分。
共对 199 例 BD 患者的临床和神经认知特征进行了描述。该样本中各亚组的分布为：BD-I，占 64%；BD-II，占 36%；60%有精神病病史；57%以抑郁为首发极性；61%BD 发病较早，25%发病居中，14%发病较晚。我们使用多元回归分析来评估神经认知变量与临床亚组之间的关系。
BD-I 诊断和升高的首发极性都与言语记忆损伤有关，升高的首发极性解释了该认知领域更多的变异（22.5%）。精神病病史和 BD-I 诊断都与语义流畅性受损有关，精神病病史解释了更多的变异（11.6%）。
言语记忆表现不佳似乎与升高的首发极性有关，语义流畅性表现不佳似乎与终生精神病病史有关。
