Suppr超能文献

抗水通道蛋白4抗体的类肽配体的发现。

Discovery of peptoid ligands for anti-aquaporin 4 antibodies.

作者信息

Raveendra Bindu L, Wu Hao, Baccala Roberto, Reddy M Muralidhar, Schilke Jessica, Bennett Jeffrey L, Theofilopoulos Argyrios N, Kodadek Thomas

机构信息

Departments of Chemistry and Cancer Biology, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA.

出版信息

Chem Biol. 2013 Mar 21;20(3):351-9. doi: 10.1016/j.chembiol.2012.12.009.

Abstract

Neuromyelitis optica (NMO) is an autoimmune inflammatory disorder of the central nervous system. In most NMO patients, autoantibodies to the water channel protein Aquaporin 4 (AQP4) are present at high levels and are thought to drive pathology by mediating complement-dependent destruction of astrocytes. Here, we apply recently developed chemical library screening technology to identify a synthetic peptoid that binds anti-AQP4 antibodies in the serum of NMO patients. This finding validates, in a well-defined human disease, that synthetic, unnatural ligands for the antigen-binding site of a disease-linked antibody can be isolated by high-throughput screening.

摘要

视神经脊髓炎(NMO)是一种中枢神经系统的自身免疫性炎症性疾病。在大多数NMO患者中,水通道蛋白4(AQP4)的自身抗体水平很高,被认为通过介导补体依赖性星形胶质细胞破坏来驱动病理过程。在此,我们应用最近开发的化学文库筛选技术,以鉴定一种能与NMO患者血清中的抗AQP4抗体结合的合成类肽。这一发现证实,在一种明确的人类疾病中,可以通过高通量筛选分离出与疾病相关抗体抗原结合位点的合成非天然配体。

相似文献

1
Discovery of peptoid ligands for anti-aquaporin 4 antibodies.
Chem Biol. 2013 Mar 21;20(3):351-9. doi: 10.1016/j.chembiol.2012.12.009.
3
Antibody to aquaporin 4 in the diagnosis of neuromyelitis optica.
PLoS Med. 2007 Apr;4(4):e133. doi: 10.1371/journal.pmed.0040133.
5
Neuromyelitis optica and anti-aquaporin-4 antibodies measured by an enzyme-linked immunosorbent assay.
J Neuroimmunol. 2008 May 30;196(1-2):181-7. doi: 10.1016/j.jneuroim.2008.03.009. Epub 2008 May 6.
6
Distinct genetic and infectious profiles in Japanese neuromyelitis optica patients according to anti-aquaporin 4 antibody status.
J Neurol Neurosurg Psychiatry. 2013 Jan;84(1):29-34. doi: 10.1136/jnnp-2012-302925. Epub 2012 Oct 4.
7
Aquaporin-4 antibodies, CNS acidosis and neuromyelitis optica: a potential link.
Med Hypotheses. 2013 Dec;81(6):1090-5. doi: 10.1016/j.mehy.2013.10.011. Epub 2013 Oct 16.
8
Anti-aquaporin-4 auto-antibodies orchestrate the pathogenesis in neuromyelitis optica.
Autoimmun Rev. 2009 Dec;9(2):132-5. doi: 10.1016/j.autrev.2009.04.004. Epub 2009 Apr 21.
9
Antibodies against aquaporin-4 in neuromyelitis optica: distinction between recurrent and monophasic patients.
Mult Scler. 2011 Dec;17(12):1527-30. doi: 10.1177/1352458511412995. Epub 2011 Aug 9.

引用本文的文献

2
ACT001 Relieves NMOSD Symptoms by Reducing Astrocyte Damage with an Autoimmune Antibody.
Molecules. 2023 Feb 2;28(3):1412. doi: 10.3390/molecules28031412.
3
A peptoid-based inhibitor of protein arginine methyltransferase 1 (PRMT1) induces apoptosis and autophagy in cancer cells.
J Biol Chem. 2022 Aug;298(8):102205. doi: 10.1016/j.jbc.2022.102205. Epub 2022 Jun 25.
4
Geared Toward Applications: A Perspective on Functional Sequence-Controlled Polymers.
ACS Macro Lett. 2021 Feb 16;10(2):243-257. doi: 10.1021/acsmacrolett.0c00855. Epub 2021 Jan 20.
5
Self-Assembly of Minimal Peptoid Sequences.
ACS Macro Lett. 2020 Apr 21;9(4):494-499. doi: 10.1021/acsmacrolett.9b01010. Epub 2020 Mar 19.
6
Protein-Catalyzed Capture Agents.
Chem Rev. 2019 Sep 11;119(17):9950-9970. doi: 10.1021/acs.chemrev.8b00660. Epub 2019 Mar 6.
8
Neuromyelitis Optica: Deciphering a Complex Immune-Mediated Astrocytopathy.
J Neuroophthalmol. 2017 Sep;37(3):291-299. doi: 10.1097/WNO.0000000000000508.
9
High-throughput Identification of DNA-Encoded IgG Ligands that Distinguish Active and Latent Mycobacterium tuberculosis Infections.
ACS Chem Biol. 2017 Jan 20;12(1):234-243. doi: 10.1021/acschembio.6b00855. Epub 2016 Dec 13.
10
Discovery of Phosphorylated Peripherin as a Major Humoral Autoantigen in Type 1 Diabetes Mellitus.
Cell Chem Biol. 2016 May 19;23(5):618-628. doi: 10.1016/j.chembiol.2016.04.006. Epub 2016 May 12.

本文引用的文献

2
Aquaporin 4 and neuromyelitis optica.
Lancet Neurol. 2012 Jun;11(6):535-44. doi: 10.1016/S1474-4422(12)70133-3. Epub 2012 May 16.
3
Complement-dependent cytotoxicity in neuromyelitis optica requires aquaporin-4 protein assembly in orthogonal arrays.
J Biol Chem. 2012 Apr 20;287(17):13829-39. doi: 10.1074/jbc.M112.344325. Epub 2012 Mar 5.
4
Serologic diagnosis of NMO: a multicenter comparison of aquaporin-4-IgG assays.
Neurology. 2012 Feb 28;78(9):665-71; discussion 669. doi: 10.1212/WNL.0b013e318248dec1. Epub 2012 Feb 1.
5
Diagnosis of Alzheimer's disease based on disease-specific autoantibody profiles in human sera.
PLoS One. 2011;6(8):e23112. doi: 10.1371/journal.pone.0023112. Epub 2011 Aug 3.
6
Application of immunosignatures to the assessment of Alzheimer's disease.
Ann Neurol. 2011 Aug;70(2):286-95. doi: 10.1002/ana.22405.
7
Binding affinity and specificity of neuromyelitis optica autoantibodies to aquaporin-4 M1/M23 isoforms and orthogonal arrays.
J Biol Chem. 2011 May 6;286(18):16516-24. doi: 10.1074/jbc.M111.227298. Epub 2011 Mar 21.
9
Identification of two major conformational aquaporin-4 epitopes for neuromyelitis optica autoantibody binding.
J Biol Chem. 2011 Mar 18;286(11):9216-24. doi: 10.1074/jbc.M110.123000. Epub 2011 Jan 6.
10
Exploring antibody recognition of sequence space through random-sequence peptide microarrays.
Mol Cell Proteomics. 2011 Mar;10(3):M110.000786. doi: 10.1074/mcp.M110.000786. Epub 2010 Nov 9.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验