Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), PO Box 164, 30100 Campus University Espinardo, Murcia, Spain.
Food Chem Toxicol. 2013 Jul;57:91-8. doi: 10.1016/j.fct.2013.03.012. Epub 2013 Mar 21.
Diseases affecting the central nervous system are spread throughout the world. As so, more efficient and safe neuroprotective drugs are required. The present study describes, for the first time, the phenolic composition and bioactivity of Jacaranda caroba (Vell.) A. DC, a species whose infusion is consumed as traditional medicine. The HPLC-DAD-ESI/MS(n) analysis revealed the presence of four dicaffeoyl acid derivatives and nine flavonoids, comprising quercetin, kaempferol and isorhamnetin derivatives. Twelve compounds are described for the first time in Jacaranda genus. Although isorhamnetin-3-O-rhmanoside-7,4'-di-O-glucoside and quercetin-3-O-(2-pentosyl)hexoside are the main metabolites in both aqueous and hydromethanolic extracts, qualitative and quantitative differences were found between them. Aqueous extract is richer in dicaffeoyl acid derivatives. Both extracts proved to be strong radicals' scavengers and effective monoamine-oxidase A inhibitors, but showed weak protection against cholinesterases' activity. The results highlight the value of J. caroba as a source of health-promoting antioxidants and antidepressant compounds.
影响中枢神经系统的疾病在全球范围内广泛存在。因此，我们需要更高效、更安全的神经保护药物。本研究首次描述了蓝花楹（Vell.）A. DC 的酚类成分和生物活性，该物种的煎剂被用作传统药物。HPLC-DAD-ESI/MS(n) 分析表明，存在四种二咖啡酰基酸衍生物和九种类黄酮，包括槲皮素、山奈酚和异鼠李素衍生物。其中 12 种化合物是在蓝花楹属中首次描述的。虽然异鼠李素-3-O-鼠李糖苷-7,4'-二-O-葡萄糖苷和槲皮素-3-O-(2-戊糖基)己糖苷是水提物和水-甲醇提取物中的主要代谢物，但它们之间存在定性和定量差异。水提取物富含二咖啡酰基酸衍生物。两种提取物均具有较强的自由基清除能力和有效的单胺氧化酶 A 抑制剂活性，但对乙酰胆碱酯酶活性的保护作用较弱。研究结果强调了蓝花楹作为具有促进健康的抗氧化剂和抗抑郁化合物的价值。
