Stücker I, Caillard J F, Collin R, Gout M, Poyen D, Hémon D
Unité de Recherches Epidémiologiques et Statistiques sur l'Environnement et la Santé, Villejuif, France.
Scand J Work Environ Health. 1990 Apr;16(2):102-7. doi: 10.5271/sjweh.1811.
The purpose of the study was to evaluate the frequency of spontaneous abortion in two groups of women. One group consisted of women regularly involved in the preparation of cancer chemotherapy perfusions and therefore considered to be exposed to cytostatic agents; the other consisted of women not occupationally exposed to such agents. The study was carried out in four French hospitals. Four hundred and sixty-six women were involved; 534 pregnancies were described in which 139 were exposed and 357 were unexposed. The results showed that the frequency of spontaneous abortion was 26% for the exposed pregnancies and 15% in the unexposed ones (odds ratio 2.0). These results do not seem to be due either to the classic risk factors of spontaneous abortion (age, cigarette consumption during pregnancy, pregnancy order) (adjusted odds ratio 1.7) or to possible errors concerning the retrospective evaluation of prior gynecologic and obstetric history.
该研究的目的是评估两组女性自然流产的发生率。一组女性经常参与癌症化疗灌注制剂的配制，因此被认为接触了细胞毒性药物；另一组女性未职业性接触此类药物。该研究在法国的四家医院开展。共有466名女性参与；记录了534次妊娠情况，其中139次妊娠为接触组，357次妊娠为未接触组。结果显示，接触组妊娠的自然流产发生率为26%，未接触组为15%（优势比为2.0）。这些结果似乎既不是由于自然流产的经典风险因素（年龄、孕期吸烟、妊娠顺序）所致（调整后优势比为1.7），也不是由于既往妇科和产科病史回顾性评估中可能存在的误差所致。
