Centre for Infectious Diseases & Microbiology Laboratory Services, Institute of Clinical Pathology & Medical Research, Westmead Hospital, Westmead, New South Wales 2145, Australia.
Future Microbiol. 2013 Apr;8(4):461-74. doi: 10.2217/fmb.13.19.
Hendra virus, a member of the family Paramyxoviridae, was first recognized following a devastating outbreak in Queensland, Australia, in 1994. The naturally acquired symptomatic infection, characterized by a rapidly progressive illness involving the respiratory system and/or CNS, has so far only been recognized in horses and humans. However, there is potential for other species to be infected, with significant consequences for animal and human health. Prevention of infection involves efforts to interrupt the bat-to-horse and horse-to-human transmission interfaces. Education and infection-control efforts remain the key to reducing risk of transmission, particularly as no effective antiviral treatment is currently available. The recent release of an equine Hendra G glycoprotein subunit vaccine is an exciting advance that offers the opportunity to curb the recent increase in equine transmission events occurring in endemic coastal regions of Australia and thereby reduce the risk of infection in humans.
亨德拉病毒属于副黏液病毒科，于 1994 年在澳大利亚昆士兰州的一次毁灭性疫情中首次被发现。这种自然获得的有症状感染以呼吸系统和/或中枢神经系统迅速进展的疾病为特征，迄今为止仅在马和人中被发现。然而，其他物种也有可能被感染，这对动物和人类的健康都有重大影响。预防感染包括努力阻断蝙蝠到马和马到人的传播界面。教育和感染控制仍然是降低传播风险的关键，特别是因为目前没有有效的抗病毒治疗方法。最近发布的马亨德拉 G 糖蛋白亚单位疫苗是一个令人兴奋的进展，为遏制澳大利亚流行沿海地区最近发生的马传播事件的增加提供了机会，从而降低了人类感染的风险。
