Henderson R D, Fung K, Cullen J B, Milne E N, Marryatt G
Can J Surg. 1975 Jan;18(1):64-9.
It has been shown that bile injected intratracheally in rabbits produces severe pulmonary edema, atelectasis, and focal hemorrhages. The authors investigated the effect of a number of solutions, including physiological concentration of bile, hydrochloric acid pH 1.0, bile salt diluted to 1%, and bile at 100% concentrations. Whenever the bile concentration exceeded 3%, none of the test animals survived. It is not possible to apply directly the results of an experimental animal study to humans. However, the severity of the pulmonary changes produced force the conclusion that bile is a potentially dangerous aspirate in humans.
已表明，经气管内注入家兔体内的胆汁会引发严重的肺水肿、肺不张和局灶性出血。作者研究了多种溶液的作用，包括生理浓度的胆汁、pH值为1.0的盐酸、稀释至1%的胆盐以及浓度为100%的胆汁。只要胆汁浓度超过3%，所有受试动物均未能存活。将实验动物研究的结果直接应用于人类是不可能的。然而，所产生的肺部变化的严重程度促使得出这样的结论：胆汁在人类中是一种潜在危险的误吸物。
