The George Institute for Global Health, University of Sydney, Australia.
Eur J Prev Cardiol. 2014 May;21(5):639-46. doi: 10.1177/2047487313484689. Epub 2013 Mar 27.
Ischemic heart disease (IHD) is the leading cause of death and disability worldwide, with higher rates among men than women. Relatively few studies on risk factor associations are available from the Asia-Pacific region, especially with regard to sex differences. Our objective was to compare the relationships between modifiable risk factors and IHD in men and women from the Asia-Pacific region.
Data from 600,445 individuals from 44 studies from the Asia Pacific Cohort Studies Collaboration, an individual patient data overview, were used. Cox models were used to evaluate the effects of risk factors on fatal and non-fatal IHD separately in men and women from Australia and New Zealand (ANZ) and Asia.
Over a median follow-up of 6.7 years, 5695 IHD events were documented. The hazard ratio for IHD, comparing men with women, was 2.14 (95% CI 1.97-2.33) in ANZ and 1.88 (95% CI 1.54-2.29) in Asia. The age-adjusted prevalence of major risk factors was generally higher in men than women, especially in ANZ. Risk factors acted broadly similarly between men and women in both Asia and ANZ, with any indications of differences tending to favor men, rather than women.
The excess risk of IHD observed in men compared with women in both Asia and ANZ may be, at least in part, a result of a more hazardous risk profile in men compared with women. The contribution of sex differences in the magnitude of the risk factor-disease associations is unlikely to be a contributing factor.
缺血性心脏病（IHD）是全球范围内导致死亡和残疾的主要原因，男性的发病率高于女性。来自亚太地区的关于危险因素相关性的研究相对较少，特别是关于性别差异方面的研究。我们的目的是比较亚太地区男性和女性中可改变的危险因素与 IHD 之间的关系。
使用来自亚太队列研究协作组织的 44 项研究中 600445 名个体的个体患者数据概述的数据。Cox 模型用于分别评估澳大利亚和新西兰（ANZ）和亚洲男性和女性中危险因素对致命和非致命 IHD 的影响。
在中位数为 6.7 年的随访期间，记录了 5695 例 IHD 事件。在 ANZ 和亚洲，男性与女性相比，IHD 的危险比分别为 2.14（95%CI 1.97-2.33）和 1.88（95%CI 1.54-2.29）。在男性中，主要危险因素的年龄调整患病率普遍高于女性，尤其是在 ANZ。在亚洲和 ANZ 中，男性和女性之间的危险因素作用大致相似，任何表明差异的倾向都有利于男性，而不是女性。
在亚洲和 ANZ 中，男性与女性相比，IHD 的风险较高，这可能至少部分归因于男性与女性相比，风险状况更为危险。性别差异在危险因素与疾病关联的程度上的贡献不太可能是一个促成因素。
