T200A 和 E227A 替换大流行 2009 年流感 A 病毒血凝素可增加致死性但降低传播性。
Substitutions T200A and E227A in the hemagglutinin of pandemic 2009 influenza A virus increase lethality but decrease transmission.
机构信息
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
出版信息
J Virol. 2013 Jun;87(11):6507-11. doi: 10.1128/JVI.00262-13. Epub 2013 Mar 27.
Abstract
We report that swine influenza virus-like substitutions T200A and E227A in the hemagglutinin (HA) of the 2009 pandemic influenza virus alter its pathogenesis and transmission. Viral replication is increased in mammalian cells. Infected mice show increased disease as measured by weight loss and lethality. Transmission in ferrets is decreased in the presence of both substitutions, suggesting that amino acids 200T and 227E are adaptive changes in the HA of swine origin influenza viruses associated with increased transmission and decreased pathogenesis.
摘要
我们报告称，2009 年大流行流感病毒血凝素（HA）中的 T200A 和 E227A 猪流感病毒类似替换改变了其发病机制和传播方式。病毒在哺乳动物细胞中的复制增加。感染的小鼠体重减轻和死亡率增加，表明疾病加重。在存在这两种替换的情况下，雪貂中的传播减少，这表明 200T 和 227E 氨基酸是与传播增加和发病机制减弱相关的猪源流感病毒 HA 的适应性变化。
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