Ghosh Roumi, Uppal Beena, Aggarwal Prabhav, Chakravarti Anita, Jha Arun Kumar
Post Graduate Student, Department of Microbiology.
J Clin Diagn Res. 2013 Feb;7(2):247-9. doi: 10.7860/JCDR/2013/5267.2738. Epub 2013 Jan 11.
The resistance to the clinically important antimicrobial agents, particularly the fluoroquinolones and the macrolides, is increasing among the Campylobacter isolates. Only limited data is available regarding the changing antimicrobial resistance pattern in the Indian scenario.
Three hundred fifty cases (ages ≤12years) of acute diarrhoea, who were admitted to a tertiary-care hospital, were investigated for Campylobacter spp. The antimicrobial susceptibilities of all the C. jejuni isolates were assessed by the disk diffusion method according to the CLSI guidelines.
A total of 36 isolates of C. jejuni were tested for their antimicrobial susceptibilities. A high degree of resistance to the fluoroquinolones (100% to Nalidixic acid and 86.66% to Ciprofloxacin) was detected in the Campylobacter isolates. The frequency of resistance against Tetracycline was 33.33% and that against Erythromycin was 22.2%. Fifteen (41.66%) isolates were multiresistant, being resistant to 3 or more antimicrobial agents.
An increased resistance to the quinolones and the macrolides and multidrug resistance warrant a reconsideration of their use as the drugs of choice in patients with severe gastroenteritis when Campylobacter is the presumed cause.
在弯曲杆菌分离株中，对临床上重要的抗菌药物，尤其是氟喹诺酮类和大环内酯类药物的耐药性正在增加。在印度的情况下，关于不断变化的抗菌药物耐药模式的数据有限。
对一家三级医院收治的350例（年龄≤12岁）急性腹泻患者进行弯曲杆菌属调查。根据CLSI指南，采用纸片扩散法评估所有空肠弯曲菌分离株的抗菌药物敏感性。
共检测了36株空肠弯曲菌的抗菌药物敏感性。在弯曲杆菌分离株中检测到对氟喹诺酮类药物的高度耐药性（对萘啶酸耐药率为100%，对环丙沙星耐药率为86.66%）。对四环素的耐药率为33.33%，对红霉素的耐药率为22.2%。15株（41.66%）分离株具有多重耐药性，对3种或更多抗菌药物耐药。
对喹诺酮类和大环内酯类药物耐药性增加以及多重耐药性，使得在弯曲杆菌被认为是病因的严重胃肠炎患者中，重新考虑将其作为首选药物使用。
