Thany Steeve H, Reynier Pascal, Lenaers Guy
Laboratoire récepteurs et canaux ioniques membranaires, UPRES EA 2647-USC INRA 1330, Université d'Angers, UFR sciences, 2, boulevard Lavoisier, 49045 Angers, France.
Med Sci (Paris). 2013 Mar;29(3):273-8. doi: 10.1051/medsci/2013293013. Epub 2013 Mar 27.
Several epidemiological studies suggest that pesticides could lead to neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. Among pesticides, insecticides appear more neurotoxic than others but the neurotoxic mechanisms leading to adverse health effects remain unclear. The currently used pesticides such as rotenone and paraquat could disrupt mitochondrial bioenergetic function, reactive oxygen metabolism, redox function and promote α-synuclein aggregation. In addition, recent studies demonstrate that genetic susceptibility to Parkinson's disease could monitor pesticide susceptibility, as demonstrated for polymorphisms in pesticide metabolizing enzymes that are involved in organophosphorus sensitivity.
多项流行病学研究表明，农药可能导致神经退行性疾病，如帕金森病和阿尔茨海默病。在农药中，杀虫剂似乎比其他农药具有更强的神经毒性，但导致不良健康影响的神经毒性机制仍不清楚。目前使用的农药，如鱼藤酮和百草枯，可能会破坏线粒体生物能量功能、活性氧代谢、氧化还原功能，并促进α-突触核蛋白聚集。此外，最近的研究表明，帕金森病的遗传易感性可以监测对农药的易感性，这在参与有机磷敏感性的农药代谢酶多态性中得到了证明。
