Antonicelli R, Onorato G, Pagelli P, Pierazzoli L, Paciaroni E
Cardiovascular Pathology Center, University of Ancona, Italy.
Clin Ther. 1990 Mar-Apr;12(2):165-71.
Twenty elderly (mean age, 69 years), hypercholesterolemic patients (low-density lipoprotein [LDL] levels greater than or equal to 160 mg/dl) were supplied a lipid-lowering diet for one month and then received 10 mg of simvastatin daily for 12 months. Total cholesterol levels fell significantly, from 304.6 mg/dl at baseline to 277.4 mg/dl after one month on the diet, to 245.9 mg/dl after one month of simvastatin, and to 216.1 mg/dl after two months of simvastatin; total cholesterol levels remained significantly lower (221.6 mg/dl at month 12). LDL levels decreased significantly, from 217.6 mg/dl at baseline to 130.4 mg/dl at month 12. High-density lipoprotein levels increased significantly only at months 2 and 3. Apolipoprotein (apo) A levels increased significantly, from 147.2 mg/dl at baseline to 217.9 mg/dl at month 12. There were no significant changes in triglyceride or apo B levels. No changes in blood pressure, heart rate, or body weight or in results of laboratory tests were noted. Few side effects were reported. It is concluded that simvastatin is safe and effective in the treatment of hypercholesterolemia in elderly patients.
二十名老年（平均年龄69岁）高胆固醇血症患者（低密度脂蛋白[LDL]水平大于或等于160mg/dl）接受了为期一个月的降脂饮食，然后每天服用10mg辛伐他汀，共12个月。总胆固醇水平显著下降，从基线时的304.6mg/dl降至饮食一个月后的277.4mg/dl，辛伐他汀治疗一个月后降至245.9mg/dl，辛伐他汀治疗两个月后降至216.1mg/dl；总胆固醇水平在第12个月时仍显著降低（221.6mg/dl）。LDL水平显著下降，从基线时的217.6mg/dl降至第12个月时的130.4mg/dl。高密度脂蛋白水平仅在第2个月和第3个月时显著升高。载脂蛋白（apo）A水平显著升高，从基线时的147.2mg/dl升至第12个月时的217.9mg/dl。甘油三酯或apo B水平无显著变化。未观察到血压、心率、体重或实验室检查结果的变化。报告的副作用很少。结论是辛伐他汀治疗老年患者高胆固醇血症安全有效。
