[自身免疫性疾病患者血液中循环免疫复合物中的抗脱氧核糖核蛋白抗体]
[Antibodies against deoxyribonucleoproteins in circulating immune complexes in the blood of patients with autoimmune diseases].
作者信息
Matl I, Hasková V, Dostál C, Kaslík J
机构信息
Katedra interního lékarství, Institutu pro dalsí vzdĕlávání lékarů a farmaceutů, Praha.
出版信息
Cas Lek Cesk. 1990 May 18;129(20):622-4.
In 40 patients with various autoimmune diseases antibodies against desoxyribonucleoprotein (DNP) were assessed by enzyme immunoanalysis (ELISA) in serum and after dissociation of the isolated precipitate of circulating immune complexes (CIC) in the presence of polyethylene glycol. The results indicate that antibodies against DNP are not specific for systemic lupus erythematosus (SLE) and can be detected in serum and in particular in CIC in various autoimmune conditions. In SLE they may be important for evaluation of the activity of the disease, in particular if estimated concurrently in serum and in CIC.
对40例患有各种自身免疫性疾病的患者，通过酶免疫分析（ELISA）检测其血清中的抗脱氧核糖核蛋白（DNP）抗体，并在聚乙二醇存在的情况下，对分离出的循环免疫复合物（CIC）沉淀物进行解离后检测。结果表明，抗DNP抗体并非系统性红斑狼疮（SLE）所特有，在各种自身免疫性疾病的血清中，尤其是在CIC中均可检测到。在SLE中，这些抗体对于评估疾病活动可能很重要，特别是当同时在血清和CIC中进行评估时。
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