心血管再生生物学的模型系统。
Model systems for cardiovascular regenerative biology.
机构信息
Boston Children's Hospital, Boston, MA 02115, USA.
出版信息
Cold Spring Harb Perspect Med. 2013 Apr 1;3(4):a014019. doi: 10.1101/cshperspect.a014019.
Abstract
There is an urgent clinical need to develop new therapeutic approaches to treat heart failure, but the biology of cardiovascular regeneration is complex. Model systems are required to advance our understanding of biological mechanisms of cardiac regeneration as well as to test therapeutic approaches to regenerate tissue and restore cardiac function following injury. An ideal model system should be inexpensive, easily manipulated, easily reproducible, physiologically representative of human disease, and ethically sound. In this review, we discuss computational, cell-based, tissue, and animal models that have been used to elucidate mechanisms of cardiovascular regenerative biology or to test proposed therapeutic methods to restore cardiac function following disease or injury.
摘要
目前，临床上急需开发新的治疗方法来治疗心力衰竭，但心血管再生的生物学机制非常复杂。我们需要建立模型系统，以加深对心脏再生生物学机制的理解，并测试各种治疗方法，以期在损伤后再生组织和恢复心脏功能。一个理想的模型系统应该成本低廉、易于操作、可重复性好、在生理学上能代表人类疾病，并且符合伦理规范。在这篇综述中，我们讨论了已被用于阐明心血管再生生物学机制或测试在疾病或损伤后恢复心脏功能的治疗方法的计算模型、基于细胞的模型、组织模型和动物模型。
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