Section of Dermatology, Department of Medical Sciences, University of Ferrara, Italy.
Arch Dermatol Res. 2013 Sep;305(7):659-64. doi: 10.1007/s00403-013-1346-5. Epub 2013 Apr 2.
Cherry angiomas (CAs) are common vascular benign skin tumors, characterized by abnormal angiogenesis, whose etiology is still unclear and poorly studied. We investigated the presence of HHV8 in CAs due to virus ability of inducing neoangiogenesis in endothelial cells. A total of 29 patients were enrolled in a randomized, controlled, blinded analysis of skin specimens including various vascular lesions. All clinical samples were anonymized and analyzed by three different biomolecular assays to minimize the risk of false positive/negative results. Results showed that 53 % of eruptive CAs harbor HHV8 sequences, with the highest viral loads in samples derived from immunosuppressed patients. By contrast, no paucilesional CAs were positive for HHV8. Considering HHV8 prevalence in the Mediterranean population (10-15 %), results obtained in eruptive CAs are significant and suggest for the first time a possible involvement of HHV8 in eruptive cherry angiomas development, particularly in the context of immunosuppression, similar to that recognized for major HHV8-induced pathologies.
樱桃状血管瘤（CAs）是一种常见的血管良性皮肤肿瘤，其特征是异常血管生成，其病因尚不清楚且研究甚少。由于病毒能够诱导内皮细胞新生血管生成，我们研究了 CAs 中是否存在 HHV8。共纳入 29 例患者进行皮肤标本的随机、对照、双盲分析，包括各种血管病变。所有临床样本均经过三种不同的生物分子检测进行了匿名分析，以最大程度降低假阳性/假阴性结果的风险。结果显示，53%的突发性 CAs 携带 HHV8 序列，免疫抑制患者的样本中病毒载量最高。相比之下，非多发性 CAs 均未检测到 HHV8。鉴于 HHV8 在地中海人群中的流行率（10-15%），在突发性 CAs 中获得的结果具有重要意义，并首次提示 HHV8 可能参与了突发性樱桃状血管瘤的发展，特别是在免疫抑制的情况下，类似于已识别的主要 HHV8 诱导的病理学。
