Darjani Abbas, Rafiei Rana, Shafaei Sareh, Rafiei Elahe, Eftekhari Hojat, Alizade Narges, Gharaei Nejad Kaveh, Rafiee Behnam, Najirad Sara
Skin Research Center, Dermatology Department, Guilan University of Medical Sciences, Razi Hospital, Sardare Jangal Street, Rasht, Iran.
Fellowship of Dermatopathology, Skin Research Center, Dermatology Department, Guilan University of Medical Sciences, Razi Hospital, Sardare Jangal Street, Rasht, Iran.
Dermatol Res Pract. 2018 May 13;2018:4639248. doi: 10.1155/2018/4639248. eCollection 2018.
Cherry angioma is the most common type of acquired cutaneous vascular proliferation which would increase with aging due to some angiogenic factors but the exact pathogenesis is unknown. Usually angiogenic factors are synthesized in human body to compensate occlusive effects of atherogenic agents such as serum lipids. Our hypothesis was that increased levels of these angiogenic factors could be a trigger for development of cherry angioma. This study has been designed to compare frequency of dyslipidemia in subjects with and without cutaneous cherry angioma.
In this case-control study, 122 cases with cherry angioma and 122 control subjects without cherry angioma were enrolled. Demographic characteristics, number of the cherry angioma lesions, and serum lipid profile were collected for all subjects. The data was analyzed using SPSS 18 software.
Mean levels of the total cholesterol, triglyceride, low-density lipoprotein, and high-density lipoprotein were higher in patients with cherry angioma compared to control subjects in which differences were significant for total cholesterol, low-density lipoprotein, and triglyceride ( < 0.05) but not for high-density lipoprotein level.
Serum lipids may have a role in producing angiogenic factors and development of cherry angioma and it seems logical to evaluate lipid profile in these cases.
樱桃状血管瘤是最常见的获得性皮肤血管增生类型，由于某些血管生成因子，其会随着年龄增长而增多，但确切发病机制尚不清楚。通常血管生成因子在人体内合成以补偿诸如血脂等致动脉粥样硬化因子的闭塞作用。我们的假设是这些血管生成因子水平升高可能是樱桃状血管瘤发生的触发因素。本研究旨在比较有和没有皮肤樱桃状血管瘤的受试者中血脂异常的发生率。
在这项病例对照研究中，纳入了122例樱桃状血管瘤患者和122例无樱桃状血管瘤的对照受试者。收集了所有受试者的人口统计学特征、樱桃状血管瘤病变数量和血脂谱。使用SPSS 18软件对数据进行分析。
与对照受试者相比，樱桃状血管瘤患者的总胆固醇、甘油三酯、低密度脂蛋白和高密度脂蛋白的平均水平更高，其中总胆固醇、低密度脂蛋白和甘油三酯的差异具有统计学意义（<0.05），但高密度脂蛋白水平差异无统计学意义。
血脂可能在产生血管生成因子和樱桃状血管瘤的发生中起作用，在这些病例中评估血脂谱似乎是合理的。
