Avanaki Mohammad R N, Hojjatoleslami Ali, Sira Mano, Schofield John B, Jones Carole, Podoleanu Adrian Gh
Research and Development Centre, School of Biosciences, University of Kent, Canterbury, Kent, UK.
Appl Opt. 2013 Apr 1;52(10):2116-24. doi: 10.1364/AO.52.002116.
Optical coherence tomography (OCT) is becoming a popular modality for skin tumor diagnosis and assessment of tumor size and margin status. We conducted a number of imaging experiments on periocular basal cell carcinoma (BCC) specimens using an OCT configuration. This configuration employs a dynamic focus (DF) procedure where the coherence gate moves synchronously with the peak of the confocal gate, which ensures better signal strength and preservation of transversal resolution from all depths. A DF-OCT configuration is used to illustrate morphological differences between the BCC and its surrounding healthy skin in OCT images. The OCT images are correlated with the corresponding histology images. To the best of our knowledge, this is the first paper to look at DF-OCT imaging in examining periocular BCC.
光学相干断层扫描（OCT）正成为一种用于皮肤肿瘤诊断以及评估肿瘤大小和边缘状态的常用方法。我们使用一种OCT配置对眼周基底细胞癌（BCC）标本进行了多项成像实验。这种配置采用动态聚焦（DF）程序，其中相干门与共焦门的峰值同步移动，这确保了更好的信号强度以及所有深度横向分辨率的保持。采用DF-OCT配置来说明OCT图像中BCC与其周围健康皮肤之间的形态差异。OCT图像与相应的组织学图像相关联。据我们所知，这是第一篇研究DF-OCT成像用于检查眼周BCC的论文。
