Division of Translational Medicine, Wadsworth Center, NYS Department of Health, PO Box 509, Albany, NY 12201 0509, USA.
Biomark Med. 2013 Apr;7(2):247-60. doi: 10.2217/bmm.12.108.
Autism spectrum disorder (ASD) represents a wide range of neurodevelopmental disorders characterized by impairments in social interaction, language, communication and range of interests. Autism is usually diagnosed in children 3-5 years of age using behavioral characteristics; thus, diagnosis shortly after birth would be beneficial for early initiation of treatment.
This retrospective study sought to identify newborns at risk for ASD utilizing bloodspot specimens in an immunoassay.
MATERIALS & METHODS: The present study utilized stored frozen specimens from ASD children already diagnosed at 15-36 months of age. The newborn specimens and controls were analyzed by immunoassay in a multiplex system that included 90 serum biomarkers and subjected to statisical analysis.
Three sets of five biomarkers associated with ASD were found that differed from control groups. The 15 candidate biomarkers were then discussed regarding their association with ASD.
This study determined that a statistically selected panel of 15 biomarkers successfully discriminated presumptive newborns at risk for ASD from those of nonaffected controls.
自闭症谱系障碍（ASD）是一种广泛的神经发育障碍，其特征是社交互动、语言、沟通和兴趣范围方面的损伤。自闭症通常在儿童 3-5 岁时使用行为特征进行诊断；因此，在出生后不久进行诊断将有利于早期开始治疗。
本回顾性研究旨在利用免疫测定法从血斑标本中识别出有患自闭症风险的新生儿。
本研究利用已经在 15-36 个月时被诊断为自闭症的儿童的冷冻储存标本。通过多指标检测系统对新生儿标本和对照组进行免疫分析，该系统包含 90 种血清生物标志物，并进行了统计学分析。
发现了与自闭症相关的三套五标志物，它们与对照组不同。然后，根据它们与自闭症的关联，讨论了这 15 个候选生物标志物。
本研究确定了一组经统计学选择的 15 个生物标志物，可以成功地区分出有患自闭症风险的疑似新生儿与未受影响的对照组。
