Harvard Medical School, Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Expert Rev Respir Med. 2013 Apr;7(2):109-12. doi: 10.1586/ers.13.1.
Post-radiotherapy bronchiolitis obliterans organizing pneumonia may occur in as many as 2.3% of women receiving radiation therapy for breast cancer. Cough and fever are common symptoms, and a quarter of these women have no symptoms. Latency period is usually within 6 months after completion of therapy but may be as long as 1 year. Pulmonary function is normal or will show slight decreases in vital capacity and diffusing capacity. Chest computed tomography studies show ground-glass opacities with air bronchograms within and outside the radiation field, and there are often peripheral triangular-shaped infiltrates. Management consists of close monitoring of women who have no symptoms or minimal symptoms, and a short-course of corticosteroid therapy for women who have symptoms and extensive bronchiolitis obliterans organizing pneumonia. The prognosis is excellent; there have been no deaths reported.
放疗后闭塞性细支气管炎伴机化性肺炎在接受乳腺癌放疗的女性中发生率高达 2.3%。咳嗽和发热是常见症状，其中四分之一的女性无症状。潜伏期通常在放疗完成后 6 个月内，但也可能长达 1 年。肺功能正常或肺活量和弥散量略有下降。胸部计算机断层扫描显示磨玻璃影，伴有和不伴有放射野内的空气支气管征，常有外周三角形浸润影。管理包括对无症状或症状轻微的女性进行密切监测，对有症状和广泛闭塞性细支气管炎伴机化性肺炎的女性进行短程皮质类固醇治疗。预后极好，尚未有死亡报告。
