多种吡嗪-2(1H)-酮化学型的多组分组装。

Multicomponent assembly of diverse pyrazin-2(1H)-one chemotypes.

机构信息

Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, Santiago de Compostela, 15782, Spain.

出版信息

J Org Chem. 2013 May 3;78(9):4402-9. doi: 10.1021/jo4003163. Epub 2013 Apr 12.

DOI:10.1021/jo4003163

PMID:23551216

Abstract

An expedient and concise Ugi-based approach for the rapid assembly of pyrazin-2(1H)-one-based frameworks has been developed. This convergent approach encompasses skeletal, functional and stereochemical diversity, exhibiting an unusually high bond-forming efficiency as well as high structure and step economies. The method involves the use of readily available commercial reagents and is an example of the reconciliation of structural complexity with operational simplicity in a time- and cost-effective manner.

摘要

已经开发出一种简便快捷的基于 Ugi 的方法，用于快速组装基于吡嗪-2(1H)-酮的框架。这种收敛方法包含了骨架、功能和立体化学多样性，表现出异常高的键形成效率以及高的结构和步骤经济性。该方法涉及使用易得的商业试剂，是在节省时间和成本的情况下，实现结构复杂性与操作简单性协调的一个范例。