基于Ugi反应构建喹喔啉化合物库的方法。

Ugi-based approaches to quinoxaline libraries.

作者信息

Azuaje Jhonny, El Maatougui Abdelaziz, García-Mera Xerardo, Sotelo Eddy

机构信息

Center for Research in Biological Chemistry and Molecular Materials (CIQUS), ‡Institute of Industrial Pharmacy, and §Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela , Santiago de Compostela 15782, Spain.

出版信息

ACS Comb Sci. 2014 Aug 11;16(8):403-11. doi: 10.1021/co500036n. Epub 2014 May 14.

DOI:10.1021/co500036n

PMID:24800648

Abstract

An expedient and concise Ugi-based unified approach for the rapid assembly of quinoxaline frameworks has been developed. This convergent and versatile method uses readily available commercial reagents, does not require advanced intermediates, and exhibits excellent bond-forming efficiency, thus exemplifying the operationally simple synthesis of quinoxaline libraries.

摘要

已经开发出一种基于Ugi反应的便捷、简洁的统一方法，用于快速组装喹喔啉骨架。这种汇聚且通用的方法使用易于获得的市售试剂，不需要高级中间体，并且具有出色的成键效率，从而例证了喹喔啉库的操作简单的合成方法。