School for Oncology and Developmental Biology, Department of Epidemiology, Maastricht University Medical Center, Maastricht, The Netherlands.
Int J Cancer. 2013 Oct 1;133(7):1701-12. doi: 10.1002/ijc.28175. Epub 2013 Apr 24.
Results from epidemiological studies suggest that alcohol drinkers have a decreased risk of lymphoid neoplasms, whereas results for myeloid neoplasms are inconsistent. However, most of these studies have used retrospective data. We examined prospectively whether alcohol consumption decreases the risk of both lymphoid and myeloid neoplasms, including most common subtypes. Moreover, we investigated whether this decreased risk is due to ethanol or other contents of specific alcoholic beverages (i.e., beer, wine and liquor). The Netherlands cohort study consisted of 120,852 individuals who completed a baseline questionnaire in 1986. After 17.3 years of follow-up, 1,375 cases of lymphoid and 245 cases of myeloid neoplasms with complete exposure information were available for analysis. Compared with abstinence, we observed for plasma cell neoplasms hazard rate ratios (HR) of 1.66 (95% confidence interval (CI), 1.21-2.29), 1.63 (95% CI, 1.17-2.27), 1.11 (95% CI, 0.75-1.64) and 0.85 (95% CI, 0.51-1.42) with daily ethanol consumption of 0.1-<5, 5-<15, 15-<30 and ≥30 g, respectively. A similar pattern was observed for chronic lymphocytic leukemia/small lymphocytic lymphoma. No associations were observed for other subtypes and for myeloid neoplasms. When results were analyzed by beverage type, no clear associations were observed. In conclusion, our study did not show an inverse association between alcohol consumption and lymphoid neoplasms. Also, no inverse association was observed with myeloid neoplasms. If any association between alcohol consumption and lymphoid neoplasms exists, our study suggests an increased risk rather than a decreased risk.
流行病学研究的结果表明，饮酒者患淋巴肿瘤的风险降低，而髓样肿瘤的结果则不一致。然而，这些研究大多使用回顾性数据。我们前瞻性地研究了饮酒是否会降低包括最常见亚型在内的淋巴和髓样肿瘤的风险。此外，我们还研究了这种风险降低是由于乙醇还是特定酒精饮料（即啤酒、葡萄酒和白酒）的其他成分所致。荷兰队列研究包括 120852 名在 1986 年完成基线问卷调查的个体。在 17.3 年的随访后，有 1375 例淋巴肿瘤和 245 例髓样肿瘤病例可获得完整的暴露信息进行分析。与戒酒者相比，我们观察到浆细胞瘤的危险率比（HR）分别为 1.66（95%置信区间（CI），1.21-2.29）、1.63（95%CI，1.17-2.27）、1.11（95%CI，0.75-1.64）和 0.85（95%CI，0.51-1.42），其对应的每日乙醇摄入量分别为 0.1-<5、5-<15、15-<30 和≥30g。慢性淋巴细胞白血病/小淋巴细胞淋巴瘤也呈现出类似的模式。对于其他亚型和髓样肿瘤，未观察到相关性。当按饮料类型分析结果时，未观察到明显的相关性。总之，我们的研究未显示饮酒与淋巴肿瘤之间存在负相关。也未观察到与髓样肿瘤的负相关。如果饮酒与淋巴肿瘤之间存在任何关联，我们的研究表明是增加风险而不是降低风险。
