血清精氨酸酶：人体非洲锥虫病治疗效果的生物标志物。
Serum arginase, a biomarker of treatment efficacy in human African trypanosomiasis.
机构信息
Laboratoire de Parasitologie, UMR 177 IRD CIRAD, Université de Bordeaux, Bordeaux, France.
出版信息
J Clin Microbiol. 2013 Jul;51(7):2379-81. doi: 10.1128/JCM.03371-12. Epub 2013 Apr 3.
Abstract
Arginase serum levels were increased in human African trypanosomiasis patients and returned to control values after treatment. Arginase hydrolyzes l-arginine to l-ornithine, which is essential for parasite growth. Moreover, l-arginine depletion impairs immune functions. Arginase may be considered as a biomarker for treatment efficacy.
摘要
血清精氨酸酶水平在人类非洲锥虫病患者中升高，并在治疗后恢复到对照值。精氨酸酶将 l-精氨酸水解为 l-鸟氨酸，这对于寄生虫的生长是必不可少的。此外，l-精氨酸耗竭会损害免疫功能。精氨酸酶可被视为治疗效果的生物标志物。
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