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术前肌内注射地佐辛可减轻腹腔镜胆囊切除术后的疼痛。

Preoperative administration of intramuscular dezocine reduces postoperative pain for laparoscopic cholecystectomy.

作者信息

Zhu Yaomin, Jing Guixia, Yuan Wei

机构信息

Department of Anesthesiology, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.

出版信息

J Biomed Res. 2011 Sep;25(5):356-61. doi: 10.1016/S1674-8301(11)60047-X.

DOI:10.1016/S1674-8301(11)60047-X
PMID:23554711
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3596732/
Abstract

Postoperative pain is the most common complaint after laparoscopic cholecystectomy. This study was carried out to evaluate whether preoperative administration of intramuscular dezocine can provide postoperative analgesia and reduce postoperative opioid consumption in patients undergoing laparoscopic cholecystectomy. Patients (ASA I or II) scheduled for laparoscopic cholecystectomy were randomly assigned into intramuscular dezocine group (group 1) or intramuscular normal saline group (group 2). Dezocine and equal volume normal saline were administered intramuscularly 10 min before the induction of anesthesia. After operation, the severity of postoperative pain, postoperative fentanyl requirement, incidence and severity of side-effects were assessed. Postoperative pain and postoperative patient-controlled fentanyl consumption were reduced significantly in group 1 compared with group 2. The incidence and severity of side effects were similar between the two groups. Preoperative single-dose administration of intramuscular dezocine 0.1 mg/kg was effective in reducing postoperative pain and postoperative patient-controlled fentanyl requirement in patients undergoing laparoscopic cholecystectomy.

摘要

术后疼痛是腹腔镜胆囊切除术后最常见的主诉。本研究旨在评估术前肌内注射地佐辛是否能为接受腹腔镜胆囊切除术的患者提供术后镇痛并减少术后阿片类药物的用量。计划行腹腔镜胆囊切除术的患者（ASA I或II级）被随机分为肌内地佐辛组（1组）或肌内生理盐水组（2组）。在麻醉诱导前10分钟肌内地佐辛和等体积生理盐水。术后，评估术后疼痛的严重程度、术后芬太尼需求量、副作用的发生率和严重程度。与2组相比，1组术后疼痛和术后患者自控芬太尼用量显著降低。两组副作用的发生率和严重程度相似。术前单次肌内注射0.1mg/kg地佐辛可有效减轻接受腹腔镜胆囊切除术患者的术后疼痛和术后患者自控芬太尼需求量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c157/3596732/2fdbb1d0d319/jbr-25-05-356-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c157/3596732/6390ee366e09/jbr-25-05-356-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c157/3596732/de87310f97f7/jbr-25-05-356-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c157/3596732/2fdbb1d0d319/jbr-25-05-356-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c157/3596732/6390ee366e09/jbr-25-05-356-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c157/3596732/de87310f97f7/jbr-25-05-356-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c157/3596732/2fdbb1d0d319/jbr-25-05-356-g003.jpg

相似文献

[1]
Preoperative administration of intramuscular dezocine reduces postoperative pain for laparoscopic cholecystectomy.

J Biomed Res. 2011-9

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Thrifty effect of subanesthetic-dose S-ketamine on postoperative opioids and its safety and analgesic effectiveness: A prospective, triple-blind, randomized controlled, polycentric clinical trial.

Ibrain. 2023-5-15

[2]
Machine learning for infection risk prediction in postoperative patients with non-mechanical ventilation and intravenous neurotargeted drugs.

Front Neurol. 2022-8-1

[3]
Dezocine is a Biased Ligand without Significant Beta-Arrestin Activation of the mu Opioid Receptor.

Transl Perioper Pain Med. 2022

[4]
Dezocine as a potent analgesic: overview of its pharmacological characterization.

Acta Pharmacol Sin. 2022-7

[5]
Rapid Detection of Dezocine in Biological Fluids Based on SERS Technology.

Anal Sci. 2021-2-10

[6]
Postoperative analgesia using dezocine alleviates depressive symptoms after colorectal cancer surgery: A randomized, controlled, double-blind trial.

PLoS One. 2020-5-26

[7]
Effects of patient-controlled analgesia with hydromorphone or sufentanil on postoperative pulmonary complications in patients undergoing thoracic surgery: a quasi-experimental study.

BMC Anesthesiol. 2018-12-19

[8]
Analgesic effect of preoperative dezocine-based local anesthesia in patients undergoing inguinal hernia repair.

J Int Med Res. 2018-12

[9]
Additive analgesic effect of dexmedetomidine and dezocine administered intrathecally in a mouse pain model.

Oncotarget. 2018-5-11

[10]
Dezocine for Preventing Postoperative Pain: A Meta-Analysis of Randomized Controlled Trials.

PLoS One. 2015-8-19

本文引用的文献

[1]
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J Laparoendosc Adv Surg Tech A. 2010-10

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Curr Opin Anaesthesiol. 2010-10

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Drugs Aging. 2010-5

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Surg Endosc. 2010-5-7

[9]
Clinical efficacy of acupuncture on the morphine-related side effects in patients undergoing spinal-epidural anesthesia and analgesia.

Chin J Integr Med. 2010-2-4

[10]
Increased efficacy of micro-opioid agonist-induced antinociception by metabotropic glutamate receptor antagonists in C57BL/6 mice: comparison with (-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid (LY235959).

Psychopharmacology (Berl). 2008-6

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