清醒镇静下食管胃十二指肠镜检查不干扰基于导管的 24 小时 pH 监测。
Esophagogastroduodenoscopy with conscious sedation does not interfere with catheter-based 24-h pH monitoring.
机构信息
Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan 333, Taiwan.
出版信息
World J Gastroenterol. 2013 Mar 21;19(11):1805-10. doi: 10.3748/wjg.v19.i11.1805.
AIM
To investigate the impact of esophagogastroduodenoscopy with conscious sedation on the subsequent 24-h catheter-based pH monitoring.
METHODS
Fifty patients with extra-esophageal symptoms of gastroesophageal reflux disease undergoing ambulatory dual-probe 24-h pH monitoring were enrolled from March 2010 to August 2011. All of the data were collected prospectively and analyzed retrospectively. Thirty-six patients (72%, group A) underwent pH monitoring shortly after esophagogastroduodenoscopy (EGD) with conscious sedation, and 14 patients (28%, group B) underwent pH monitoring without conscious sedation. The 24-h pH data from two time periods were analyzed: the first 4 h (Period I) and the remaining time of the study (Period II).
RESULTS
The mean age of the patients was 49.6 ± 12.5 years; 20 patients (40%) were men. The baseline data, including age, sex, body mass index, reflux esophagitis, the Reflux Symptom Index, and the Reflux Findings Score, were comparable between the two groups. The percentage of total time with a pH < 4 and the frequency of acid reflux during Period I were not significantly different between the two groups, as measured using both pharyngeal (0.03% ± 0.10% vs 0.07% ± 0.16%, P = 0.32; and 0.07 ± 0.23 episodes/h vs 0.18 ± 0.47 episodes/h, P = 0.33, respectively) and esophageal probes (0.96% ± 1.89% vs 0.42% ± 0.81%, P = 0.59; and 0.74 ± 1.51 episodes/h vs 0.63 ± 0.97 episodes/h, P = 0.49, respectively). The percentage of total time with a pH < 4 and the frequency of acid reflux were also not significantly different between Periods I and II in group A patients, as measured using both pharyngeal (0.03% ± 0.10% vs 0.23% ± 0.85%, P = 0.21; and 0.07 ± 0.23 episodes/h vs 0.29 ± 0.98 episodes/h, P = 0.22, respectively) and esophageal probes (0.96% ± 1.89% vs 1.11% ± 2.57%, P = 0.55; and 0.74 ± 1.51 episodes/h vs 0.81 ± 1.76 episodes/h, P = 0.55, respectively).
CONCLUSION
EGD with conscious sedation does not interfere with the results of subsequent 24-h pH monitoring in patients with extra-esophageal symptoms of gastroesophageal reflux disease.
目的
研究清醒镇静下食管胃十二指肠镜检查对随后 24 小时 pH 监测的影响。
方法
2010 年 3 月至 2011 年 8 月期间，共有 50 例食管外症状性胃食管反流病患者接受了门诊双探头 24 小时 pH 监测。所有数据均前瞻性收集并回顾性分析。36 例（72%，A 组）患者在清醒镇静下食管胃十二指肠镜检查后立即进行 pH 监测，14 例（28%，B 组）患者在无镇静下进行 pH 监测。分析了两个时间段的 24 小时 pH 数据：前 4 小时（第 I 期）和研究的剩余时间（第 II 期）。
结果
患者的平均年龄为 49.6 ± 12.5 岁；20 例（40%）为男性。两组患者的基线数据，包括年龄、性别、体重指数、反流性食管炎、反流症状指数和反流发现评分，均无显著差异。第 I 期时，使用咽部（0.03%±0.10%比 0.07%±0.16%，P=0.32；0.07±0.23 次/小时比 0.18±0.47 次/小时，P=0.33）和食管探头（0.96%±1.89%比 0.42%±0.81%，P=0.59；0.74±1.51 次/小时比 0.63±0.97 次/小时，P=0.49）测量的总 pH 值<4 的时间百分比和酸反流频率无显著差异。A 组患者第 I 期和第 II 期时，使用咽部（0.03%±0.10%比 0.23%±0.85%，P=0.21；0.07±0.23 次/小时比 0.29±0.98 次/小时，P=0.22）和食管探头（0.96%±1.89%比 1.11%±2.57%，P=0.55；0.74±1.51 次/小时比 0.81±1.76 次/小时，P=0.55）测量的总 pH 值<4 的时间百分比和酸反流频率也无显著差异。
结论
清醒镇静下食管胃十二指肠镜检查不会影响食管外症状性胃食管反流病患者随后 24 小时 pH 监测的结果。
Zotero 插件