Department of Orthopedics, 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, P.R. China.
Biomarkers. 2013 May;18(3):216-20. doi: 10.3109/1354750X.2013.766262. Epub 2013 Apr 5.
This study aims to detect S100A12 in serum and synovial fluid (SF) of knee osteoarthritis (OA) patients and to investigate their correlation with clinical severity of the disease. This study enrolled 198 OA patients and 84 healthy controls. The radiological/symptomatic severity of the disease was assessed by the Kellgren-Lawrence (KL) grading system/Western Ontario McMaster University Osteoarthritis (WOMAC) scores. We demonstrated that S100A12 levels in SF but not serum were independently associated with KL grades and WOMAC scores. These results suggested that the S100A12 in SF might be a potential biomarker for predicting the development and progression of knee OA.
本研究旨在检测膝骨关节炎（OA）患者血清和滑液（SF）中的 S100A12，并探讨其与疾病严重程度的相关性。本研究纳入了 198 名 OA 患者和 84 名健康对照者。采用 Kellgren-Lawrence（KL）分级系统/西部安大略省麦克马斯特大学骨关节炎（WOMAC）评分评估疾病的放射学/症状严重程度。我们发现 SF 中的 S100A12 水平与 KL 分级和 WOMAC 评分独立相关，但血清中 S100A12 水平则不然。这些结果提示 SF 中的 S100A12 可能是预测膝 OA 发生和进展的潜在生物标志物。
