• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Heart repair by cardiac reprogramming.

作者信息

Nam Young-Jae, Song Kunhua, Olson Eric N

机构信息

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

出版信息

Nat Med. 2013 Apr;19(4):413-5. doi: 10.1038/nm.3147.

DOI:10.1038/nm.3147
PMID:23558630
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3790637/
Abstract
摘要

相似文献

1
Heart repair by cardiac reprogramming.通过心脏重编程进行心脏修复。
Nat Med. 2013 Apr;19(4):413-5. doi: 10.1038/nm.3147.
2
An emerging consensus on cardiac regeneration.关于心脏再生的新共识。
Nat Med. 2014 Dec;20(12):1386-93. doi: 10.1038/nm.3764.
3
Heart regeneration and repair after myocardial infarction: translational opportunities for novel therapeutics.心肌梗死后的心脏再生和修复：新型治疗方法的转化机会。
Nat Rev Drug Discov. 2017 Oct;16(10):699-717. doi: 10.1038/nrd.2017.106. Epub 2017 Jul 21.
4
Hope for a broken heart?一颗破碎的心还有希望吗？
Cell. 2003 Sep 19;114(6):658-9. doi: 10.1016/s0092-8674(03)00718-9.
5
Current outlook of cardiac stem cell therapy towards a clinical application.心脏干细胞治疗临床应用的当前展望。
Heart. 2013 Dec;99(23):1772-84. doi: 10.1136/heartjnl-2012-303308. Epub 2013 Mar 22.
6
Embryonic stem cells: differentiation into cardiomyocytes and potential for heart repair and regeneration.胚胎干细胞：分化为心肌细胞以及心脏修复与再生的潜力。
Coron Artery Dis. 2005 Mar;16(2):111-6. doi: 10.1097/00019501-200503000-00006.
7
The existence of myocardial repair: mechanistic insights and enhancements.心肌修复的存在：机制见解与增强。
Cardiol Rev. 2013 May-Jun;21(3):111-20. doi: 10.1097/CRD.0b013e318289d7a9.
8
Potentiating the naturally occurring process for repair of damaged heart.增强受损心脏自然修复的过程。
Curr Pharm Des. 2014;20(12):1950-63. doi: 10.2174/13816128113199990447.
9
Strategies for cardiac regeneration and repair.心脏再生与修复策略。
Sci Transl Med. 2014 Jun 4;6(239):239rv1. doi: 10.1126/scitranslmed.3006681.
10
Regenerative medicine: Reprogramming the injured heart.再生医学：对受损心脏进行重编程。
Nature. 2012 May 31;485(7400):585-6. doi: 10.1038/485585a.

引用本文的文献

1
C166 EVs potentiate miR cardiac reprogramming via miR-148a-3p.C166细胞外囊泡通过miR-148a-3p增强miR介导的心脏重编程。
J Mol Cell Cardiol. 2024 May;190:48-61. doi: 10.1016/j.yjmcc.2024.04.002. Epub 2024 Apr 4.
2
The regulatory role of pioneer factors during cardiovascular lineage specification - A mini review.先驱因子在心血管谱系特化过程中的调控作用——一篇综述短文
Front Cardiovasc Med. 2022 Aug 23;9:972591. doi: 10.3389/fcvm.2022.972591. eCollection 2022.
3
Signaling cascades in the failing heart and emerging therapeutic strategies.衰竭心脏中的信号级联反应和新兴治疗策略。
Signal Transduct Target Ther. 2022 Apr 23;7(1):134. doi: 10.1038/s41392-022-00972-6.
4
Bioengineering Methods in MicroRNA-Mediated Direct Reprogramming of Fibroblasts Into Cardiomyocytes.微小RNA介导的成纤维细胞直接重编程为心肌细胞中的生物工程方法
Front Cardiovasc Med. 2021 Oct 25;8:750438. doi: 10.3389/fcvm.2021.750438. eCollection 2021.
5
Bioengineering Technologies for Cardiac Regenerative Medicine.用于心脏再生医学的生物工程技术
Front Bioeng Biotechnol. 2021 Jun 3;9:681705. doi: 10.3389/fbioe.2021.681705. eCollection 2021.
6
Regulation of cardiomyocyte fate plasticity: a key strategy for cardiac regeneration.调控心肌细胞命运可塑性：心脏再生的关键策略。
Signal Transduct Target Ther. 2021 Jan 27;6(1):31. doi: 10.1038/s41392-020-00413-2.
7
Controlling cardiac fibrosis through fibroblast state space modulation.通过成纤维细胞状态空间调节控制心脏纤维化。
Cell Signal. 2021 Mar;79:109888. doi: 10.1016/j.cellsig.2020.109888. Epub 2020 Dec 16.
8
The Future of Direct Cardiac Reprogramming: Any Cocktail Variety?直接心脏重编程的未来：鸡尾酒疗法？
Int J Mol Sci. 2020 Oct 26;21(21):7950. doi: 10.3390/ijms21217950.
9
Toward Cardiac Regeneration: Combination of Pluripotent Stem Cell-Based Therapies and Bioengineering Strategies.迈向心脏再生：基于多能干细胞的疗法与生物工程策略的结合
Front Bioeng Biotechnol. 2020 May 27;8:455. doi: 10.3389/fbioe.2020.00455. eCollection 2020.
10
Ghrelin protects the myocardium with hypoxia/reoxygenation treatment through upregulating the expression of growth hormone, growth hormone secretagogue receptor and insulin-like growth factor-1, and promoting the phosphorylation of protein kinase B.生长激素释放肽受体通过上调生长激素、生长激素释放肽受体和胰岛素样生长因子-1的表达，促进蛋白激酶 B 的磷酸化，从而保护心肌免受缺氧/复氧处理。
Int J Mol Med. 2018 Dec;42(6):3037-3046. doi: 10.3892/ijmm.2018.3886. Epub 2018 Sep 18.

本文引用的文献

1
In vivo cardiac cellular reprogramming efficacy is enhanced by angiogenic preconditioning of the infarcted myocardium with vascular endothelial growth factor.血管内皮生长因子预处理梗死心肌可增强体内心脏细胞重编程的效果。
J Am Heart Assoc. 2012 Dec;1(6):e005652. doi: 10.1161/JAHA.112.005652. Epub 2012 Dec 19.
2
Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18.通过表达 Tbx18 将静止的心肌细胞直接转化为起搏细胞。
Nat Biotechnol. 2013 Jan;31(1):54-62. doi: 10.1038/nbt.2465. Epub 2012 Dec 16.
3
Conversion of human fibroblasts to angioblast-like progenitor cells.人成纤维细胞向血管母细胞样祖细胞的转化。
Nat Methods. 2013 Jan;10(1):77-83. doi: 10.1038/nmeth.2255. Epub 2012 Dec 2.
4
Induction of cardiomyocyte-like cells in infarct hearts by gene transfer of Gata4, Mef2c, and Tbx5.通过基因转染 Gata4、Mef2c 和 Tbx5 在梗死心脏中诱导心肌细胞样细胞。
Circ Res. 2012 Oct 12;111(9):1147-56. doi: 10.1161/CIRCRESAHA.112.271148. Epub 2012 Aug 28.
5
Direct reprogramming of fibroblasts into endothelial cells capable of angiogenesis and reendothelialization in tissue-engineered vessels.将成纤维细胞直接重编程为内皮细胞，使其能够在组织工程血管中生成血管和再内皮化。
Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13793-8. doi: 10.1073/pnas.1205526109. Epub 2012 Aug 6.
6
Myocardial Notch signaling reprograms cardiomyocytes to a conduction-like phenotype.心肌 Notch 信号转导将心肌细胞重编程为传导样表型。
Circulation. 2012 Aug 28;126(9):1058-66. doi: 10.1161/CIRCULATIONAHA.112.103390. Epub 2012 Jul 26.
7
Heart repair by reprogramming non-myocytes with cardiac transcription factors.心脏转录因子对非心肌细胞的重编程实现心脏修复。
Nature. 2012 May 13;485(7400):599-604. doi: 10.1038/nature11139.
8
MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes.microRNA 介导的心肌成纤维细胞体外和体内直接重编程为心肌细胞。
Circ Res. 2012 May 25;110(11):1465-73. doi: 10.1161/CIRCRESAHA.112.269035. Epub 2012 Apr 26.
9
In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes.在体重编程鼠心肌成纤维细胞为诱导性心肌细胞。
Nature. 2012 May 31;485(7400):593-8. doi: 10.1038/nature11044.
10
T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells.T 盒转录因子 TBX3 将成熟的心肌细胞重编程为起搏样细胞。
Cardiovasc Res. 2012 Jun 1;94(3):439-49. doi: 10.1093/cvr/cvs120. Epub 2012 Mar 14.