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丙型肝炎管理的最新进展:拉丁美洲肝病学会制定的基于蛋白酶抑制剂的三联疗法指南。

An update on the management of hepatitis C: guidelines for protease inhibitor-based triple therapy from the Latin American Association for the Study of the Liver.

机构信息

Liver Research Unit, Medica Sur Clinic & Foundation. Mexico City, Mexico.

出版信息

Ann Hepatol. 2013 Mar-Apr;12 Suppl 2:s3-35.

PMID:23559487
Abstract

Hepatitis C is a common cause of end-stage liver disease, and the main indication for liver transplantation in Latin America. Treatment of hepatitis C infected patients improves important long-term outcomes as mortality. Sustained viral response is reached in near 50% of patients with the previous management based in pegylated interferon and ribavirin. Recently new drugs were available increasing sustained viral response significantly, changing the standard of care to triple therapy. This guidelines provides a framework for practitioner in Latin America, to the management of patients with hepatitis C chronic infection.

摘要

丙型肝炎是终末期肝病的常见病因,也是拉丁美洲进行肝移植的主要指征。治疗丙型肝炎感染患者可改善重要的长期预后,如死亡率。在以前基于聚乙二醇干扰素和利巴韦林的治疗中,近 50%的患者达到了持续病毒学应答。最近,新的药物问世,显著提高了持续病毒学应答率,改变了三联疗法的治疗标准。本指南为拉丁美洲的临床医生提供了一个框架,用于管理慢性丙型肝炎感染患者。

相似文献

1
An update on the management of hepatitis C: guidelines for protease inhibitor-based triple therapy from the Latin American Association for the Study of the Liver.丙型肝炎管理的最新进展:拉丁美洲肝病学会制定的基于蛋白酶抑制剂的三联疗法指南。
Ann Hepatol. 2013 Mar-Apr;12 Suppl 2:s3-35.
2
Triple therapy with first-generation protease inhibitors for patients with genotype 1 chronic hepatitis C: recommendations of the Italian association for the study of the liver (AISF).第一代蛋白酶抑制剂用于基因1型慢性丙型肝炎患者的三联疗法:意大利肝脏研究协会(AISF)的建议
Dig Liver Dis. 2014 Jan;46(1):18-24. doi: 10.1016/j.dld.2013.08.243. Epub 2013 Oct 9.
3
The role of triple therapy with protease inhibitors in hepatitis C virus genotype 1 naïve patients.蛋白酶抑制剂三联疗法在初治丙型肝炎病毒基因型 1 患者中的作用。
Liver Int. 2011 Jan;31 Suppl 1:53-7. doi: 10.1111/j.1478-3231.2010.02391.x.
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New protease inhibitors and direct-acting antivirals for hepatitis C: interferon's long goodbye.用于丙型肝炎的新型蛋白酶抑制剂和直接作用抗病毒药物:干扰素的漫长告别。
Gut. 2012 Dec;61(12):1647-52. doi: 10.1136/gutjnl-2012-302910. Epub 2012 Aug 30.
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Effects of Smoking on Pegylated Interferon alpha 2a and First Generation Protease Inhibitor-based Antiviral Therapy in Naïve Patients Infected with Hepatitis C Virus Genotype 1.吸烟对初治丙型肝炎病毒1型感染患者聚乙二醇化干扰素α-2a及第一代蛋白酶抑制剂类抗病毒治疗的影响
J Gastrointestin Liver Dis. 2016 Mar;25(1):15-24. doi: 10.15403/jgld.2014.1121.251.a2a.
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Impact of ribavirin on HCV replicon RNA decline during treatment with interferon-α and the protease inhibitors boceprevir or telaprevir.利巴韦林对α干扰素与蛋白酶抑制剂博赛匹韦或特拉匹韦联合治疗期间丙型肝炎病毒复制子RNA下降的影响
Antivir Ther. 2011;16(5):695-704. doi: 10.3851/IMP1821.
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Protease inhibitor-based triple therapy in chronic hepatitis C: guidelines by the French Association for the Study of the Liver.基于蛋白酶抑制剂的慢性丙型肝炎三联疗法:法国肝病学会指南。
Liver Int. 2012 Nov;32(10):1477-92. doi: 10.1111/j.1478-3231.2012.02856.x. Epub 2012 Aug 14.
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[Position paper of the Catalan Society of Gastroenterology: treatment of Genotype 1 Chronic Hepatitis C Virus with Triple Therapy].[加泰罗尼亚胃肠病学会立场文件:三联疗法治疗1型慢性丙型肝炎病毒]
Gastroenterol Hepatol. 2012 Nov;35(9):667-74. doi: 10.1016/j.gastrohep.2012.03.005. Epub 2012 May 3.
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Impact of HCV protease-inhibitor-based triple therapy for chronic HCV genotype 1 infection.基于丙型肝炎病毒蛋白酶抑制剂的三联疗法对慢性丙型肝炎1型感染的影响。
Antivir Ther. 2011;16(8):1187-201. doi: 10.3851/IMP1934.
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[Treatment of chronic hepatitis viral C: new associations].[慢性丙型肝炎病毒感染的治疗:新联合疗法]
Presse Med. 2013 Jun;42(6 Pt 1):977-82. doi: 10.1016/j.lpm.2012.06.019. Epub 2012 Sep 27.

引用本文的文献

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Artificial Intelligence-Based Ensemble Learning Model for Prediction of Hepatitis C Disease.基于人工智能的集成学习模型预测丙型肝炎疾病。
Front Public Health. 2022 Apr 27;10:892371. doi: 10.3389/fpubh.2022.892371. eCollection 2022.
2
Chronic hepatitis C genotype 1 virus: who should wait for treatment?慢性丙型肝炎1型病毒:谁应该等待治疗?
World J Gastroenterol. 2014 Mar 21;20(11):2867-75. doi: 10.3748/wjg.v20.i11.2867.