College of Plant Science, Jilin University, Changchun, 130062, P. R. China.
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193, P. R. China.
Chem Biodivers. 2020 Mar;17(3):e1900744. doi: 10.1002/cbdv.201900744. Epub 2020 Feb 20.
A new azaphilone, chaephilone E, eight azaphilone derivatives, and three chaetoglobosins were isolated from endophytic fungi Chaetomium globosum. The structures of the compounds were elucidated by 1D and 2D NMR as well as HR-ESI-MS data, and the absolute configuration of chaephilone E was established on the basis of electronic circular dichroism and NOESY spectrum. The activity of chaephilone E was evaluated via the cytotoxic assay (human hepatoma cell lines HepG-2) and brine shrimp (Artemia salina) bioassay.
从内生真菌 Chaetomium globosum 中分离得到一种新的氮杂菲酮 chaephilone E、八种氮杂菲酮衍生物和三种 chaetoglobosins。通过 1D 和 2D NMR 以及 HR-ESI-MS 数据阐明了化合物的结构，并根据电子圆二色谱和 NOESY 谱确定了 chaephilone E 的绝对构型。通过细胞毒性测定（人肝癌细胞系 HepG-2）和盐水虾（Artemia salina）生物测定评估了 chaephilone E 的活性。
