Bourquia A, Jabrane A J, Ramdani B, Zaid D
Service de Néphrologie-Hémodialyse, CHU IBN-ROCHD, Casablanca, Maroc.
Presse Med. 1988 Oct 15;17(35):1798-800.
Paraphenylenediamine (PPD) poisoning has been known for many years, but few studies have been devoted to the subject. We report 4 cases, seen in the nephrology department, concerning women aged from 18 to 35 years who had tried to commit suicide by drinking varying amounts of that hair dye. The initial symptom was acute asphyxia which required emergency tracheotomy in 3 cases. Thereafter, the most important visceral damage was acute renal failure, usually with oliguria or anuria, for which haemodialysis was performed in 2 cases. In these patients treated at an early stage the mid- and long-term prognosis was satisfactory. Rhabdomyolysis is the principal mechanism underlying PPD systemic toxicity; it is, in particular, responsible for the renal failure observed. The selling of PPD hair dye should be restricted by law.
对苯二胺（PPD）中毒已为人所知多年，但针对该主题的研究甚少。我们报告了在肾内科所见的4例病例，涉及年龄在18至35岁之间的女性，她们饮用了不同量的那种染发剂试图自杀。初始症状为急性窒息，3例患者需要紧急气管切开术。此后，最重要的内脏损害是急性肾衰竭，通常伴有少尿或无尿，2例患者接受了血液透析。在这些早期接受治疗的患者中，中长期预后良好。横纹肌溶解是PPD全身毒性的主要机制；尤其它是导致所观察到的肾衰竭的原因。PPD染发剂的销售应受到法律限制。
