Roy Sanchita, Majumdar Adhip P N
John D Dingell VA Medical Centre, 4646 John R Street, Detroit, MI-48201, USA ; Department of Internal Medicine, Wayne State University, Detroit, MI-48201, USA.
J Stem Cell Res Ther. 2012 Dec 17;Suppl 7(6). doi: 10.4172/2157-7633.S7-006.
Colorectal cancer (CRC), an age-related disease, is the third most common cancer in the world. Although sporadic CRC, that affects 80-85% of CRC patients, is a multi-step process initiated by APC gene mutation, it is becoming increasingly evident that a small sub-population of cells termed cancer stem/stem-like cells (CSCs/CSLCs) plays critical roles in the progression of this malignancy specially the recurrence and drug resistance. The current review will summarize genetic and epigenetic changes observed at different stages in the progression of sporadic CRC. In addition, roles of miRNAs that control gene expression and CSCs/CSLCs in regulating proliferation, differentiation, and survival of the colon cancer cells will be summarized.
结直肠癌（CRC）是一种与年龄相关的疾病，是全球第三大常见癌症。虽然散发性CRC影响80%-85%的CRC患者，是由APC基因突变引发的多步骤过程，但越来越明显的是，一小部分被称为癌症干细胞/干细胞样细胞（CSCs/CSLCs）的细胞在这种恶性肿瘤的进展中，特别是在复发和耐药方面起着关键作用。本综述将总结散发性CRC进展不同阶段观察到的基因和表观遗传变化。此外，还将总结控制基因表达的miRNA以及CSCs/CSLCs在调节结肠癌细胞增殖、分化和存活中的作用。
