Institute for Human Infections and Immunity, Center for Tropical Diseases, and Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Am J Trop Med Hyg. 2013 Jun;88(6):1170-9. doi: 10.4269/ajtmh.12-0674. Epub 2013 Apr 8.
O'nyong-nyong virus (ONNV), an alphavirus closely related to chikungunya virus (CHIKV), has caused three major epidemics in Africa since 1959. Both ONNV and CHIKV produce similar syndromes with fever, rash, and debilitating arthralgia. To determine the roles of the innate and adaptive immune responses, we infected different knockout mice with two strains of ONNV (SG650 and MP30). Wild-type, RAG1 KO, and IFNγR KO mice showed no signs of illness or viremia. The STAT1 KO and A129 mice exhibited 50-55% mortality when infected with SG650. Strain SG650 was more virulent in the STAT1 KO and A129 than MP30. Deficiency in interferon α/β signaling (A129 and STAT1 KO) leaves mice susceptible to lethal disease; whereas a deficiency of interferon γ signaling alone had no effect on survival. Our findings highlight the importance of type I interferon in protection against ONNV infection, whereas the adaptive immune system is relatively unimportant in the acute infection.
奥尼永永病毒（ONNV）是一种与基孔肯雅病毒（CHIKV）密切相关的甲病毒，自 1959 年以来已在非洲引发了三次大流行。ONNV 和 CHIKV 都会引起类似的综合征，包括发热、皮疹和关节疼痛。为了确定固有免疫和适应性免疫反应的作用，我们用两种 ONNV 株（SG650 和 MP30）感染了不同的基因敲除小鼠。野生型、RAG1 KO 和 IFNγR KO 小鼠没有出现任何疾病或病毒血症的迹象。当感染 SG650 时，STAT1 KO 和 A129 小鼠的死亡率为 50-55%。SG650 株在 STAT1 KO 和 A129 中的毒力比 MP30 更强。干扰素 α/β信号通路缺陷（A129 和 STAT1 KO）会使小鼠易患致死性疾病；而单独缺乏干扰素 γ 信号通路对存活没有影响。我们的研究结果强调了 I 型干扰素在预防 ONNV 感染中的重要性，而适应性免疫系统在急性感染中相对不重要。
