鸡蛋花根皮中一种生物活性生物碱的抗过敏和抗炎活性
Anti-anaphylactic and anti-inflammatory activities of a bioactive alkaloid from the root bark of Plumeria acutifolia Poir.
作者信息
Vijayalakshmi A, Ravichandiran V, Velraj Malarkodi, Hemalatha S, Sudharani G, Jayakumari S
机构信息
Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels University, Pallavaram, Chennai-117, Tamilnadu, France.
出版信息
Asian Pac J Trop Biomed. 2011 Oct;1(5):401-5. doi: 10.1016/S2221-1691(11)60088-9.
OBJECTIVE
To investigate the anti-anaphylactic, anti-inflammatory and membrane stabilizing properties of plumerianine (compound 1) isolated from the root bark of Plumeria acutifolia Poir.
METHODS
The anti-anaphylactic activity of compound 1 (10, 25 and 50 mg/kg) was studied by using models such as passive cutaneous anaphylaxis, passive paw anaphylaxis and its anti-inflammatory activity against carrageenin induced paw edema and cotton pellet granuloma in albino rats was also investigated using ketotifen and indomethacin as reference drugs.
RESULTS
A dose-dependent beneficial effect was observed on leakage of evans blue dye in skin challenged with antigen and on paw anaphylaxis induced by antiserum. The compound 1 also exhibited significant (P<0.01) inhibition of rat paw edema and granuloma tissue formation, including significant protection of RBC against the haemolytic effect of hypotonic solution, an indication of membrane-stabilizing activity.
CONCLUSIONS
Anti-anaphylactic activity of compound 1 may be possibly due to inhibition of the release of various inflammatory mediators. Anti-inflammatory activity of compound may be related to the inhibition of the early phase and late phase of inflammatory events.
目的
研究从白兰花根皮中分离得到的鸡蛋花宁（化合物1）的抗过敏、抗炎及膜稳定特性。
方法
采用被动皮肤过敏、被动足趾过敏等模型研究化合物1（10、25和50mg/kg）的抗过敏活性，以酮替芬和吲哚美辛作为参比药物，研究其对卡拉胶诱导的大鼠足趾水肿和棉球肉芽肿的抗炎活性。
结果
在抗原攻击皮肤时观察到化合物1对伊文思蓝染料渗漏及抗血清诱导的足趾过敏具有剂量依赖性有益作用。化合物1对大鼠足趾水肿和肉芽肿组织形成也表现出显著（P<0.01）抑制作用，包括对红细胞抵抗低渗溶液溶血作用的显著保护作用，这表明其具有膜稳定活性。
结论
化合物1的抗过敏活性可能归因于抑制多种炎症介质的释放。化合物的抗炎活性可能与抑制炎症事件的早期和晚期有关。
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