阿朴卡林碱在正常血压 Wistar 大鼠中的降压活性。
Antihypertensive Activity of the Alkaloid Aspidocarpine in Normotensive Wistar Rats.
机构信息
Laboratório de Tecnologia de Alimentos, CCTA, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Rio de Janeiro 28013-602, Brazil.
Laboratório de Clínica e Cirurgia Animal, CCTA, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes 28013-602, Brazil.
出版信息
Molecules. 2022 Oct 14;27(20):6895. doi: 10.3390/molecules27206895.
The alkaloid Aspidocarpine was isolated from the bark of Aspidosperma desmanthum. Its structure was elucidated by the spectral data of 1H and 13C-NMR (1D and 2D) and high-resolution mass spectrometry (HRESIMS). The antihypertensive activity was investigated by intravenous infusion in Wistar rats. This alkaloid significantly reduced (p < 0.05) the systolic, median, and diastolic blood pressures of rodents, without causing motor incoordination and imbalance in the rotarod test. The results indicate that the alkaloid Aspidocarpine exerts its antihypertensive activity without causing sedation or the impairment of motor functions.
从垂枝红千层(Aspidosperma desmanthum)树皮中分离得到生物碱阿朴卡林。通过 1H 和 13C-NMR(1D 和 2D)及高分辨质谱(HR-ESI-MS)的光谱数据阐明了其结构。采用静脉输注法在 Wistar 大鼠中研究了其降压活性。该生物碱可显著降低( p < 0.05)啮齿动物的收缩压、中位血压和舒张压，而不会引起运动不协调和在转棒试验中失衡。结果表明，生物碱阿朴卡林发挥其降压活性而不会引起镇静或运动功能损害。
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