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2
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J Investig Allergol Clin Immunol. 2010;20(1):80-3.
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Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL-7402 human hepatocellular carcinoma cells and is effective via oral administration.葫芦素 B 诱导 BEL-7402 人肝癌细胞凋亡和 S 期细胞周期阻滞，并具有口服有效性。
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4
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J Altern Complement Med. 2009 Dec;15(12):1273-4. doi: 10.1089/acm.2009.0241.
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Interaction of cucurbitacins with human serum albumin: Thermodynamic characteristics and influence on the binding of site specific ligands.葫芦素与人类血清白蛋白的相互作用：热力学特征及对位点特异性配体结合的影响。
J Photochem Photobiol B. 2009 Jun 3;95(3):189-95. doi: 10.1016/j.jphotobiol.2009.03.005. Epub 2009 Mar 25.
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喷瓜乙醇提取物对金黄色葡萄球菌和白色念珠菌的作用。

Effect of ethanolic extract of Ecballium elaterium against Staphylococcus aureus and Candida albicans.

作者信息

Adwan Ghaleb, Salameh Yousef, Adwan Kamel

机构信息

Department of Biology and Biotechnology, An-Najah N. University, P. O. Box (7)-Nablus, Palestine.

出版信息

Asian Pac J Trop Biomed. 2011 Dec;1(6):456-60. doi: 10.1016/S2221-1691(11)60100-7.

DOI:10.1016/S2221-1691(11)60100-7
PMID:23569813
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3614208/
Abstract

OBJECTIVE

To evaluate the antimicrobial activity of ethanolic extract of Ecballium elaterium (E. elaterium) fruits alone against Staphylococcus aureus (S. aureus) strains and Candida albicans (C. albicans) strains, or in combination with penicillin against Staphylococcus areus strains.

METHODS

Evaluation of the antimicrobial activity or synergy interaction was carried out using microdilution method.

RESULTS

The results showed that ethanolic extract of E. elaterium fruits has antimicrobial activity against methicillin resistant S. aureus (MRSA), methicillin sensitive S. aureus (MSSA) and C. albicans. This extract showed a significant decrease in minimum inhibitory concentrations (MIC) of penicillin against both MRSA and MSSA strains. Fractional inhibitory concentration index (FIC) between penicillin and ethanolic extract of E. elaterium fruits against these test strains was less than 0.5.

CONCLUSIONS

This study suggests that ethanolic extract of E. elaterium fruits has antimicrobial activity against S. aureus and C. albicans and there is a possibility of concurrent use of penicillin and E. elaterium extract in combination in the treatment of infections caused by MRSA and MSSA strains. A wider study is needed to identify the effective components, the mode of action and the possible toxic effect in vivo of these ingredients.

摘要

目的

评估喷瓜果实乙醇提取物单独对金黄色葡萄球菌菌株和白色念珠菌菌株的抗菌活性，以及与青霉素联合对金黄色葡萄球菌菌株的抗菌活性。

方法

采用微量稀释法评估抗菌活性或协同相互作用。

结果

结果表明，喷瓜果实乙醇提取物对耐甲氧西林金黄色葡萄球菌（MRSA）、甲氧西林敏感金黄色葡萄球菌（MSSA）和白色念珠菌具有抗菌活性。该提取物使青霉素对MRSA和MSSA菌株的最低抑菌浓度（MIC）显著降低。青霉素与喷瓜果实乙醇提取物对这些受试菌株的联合抑菌浓度指数（FIC）小于0.5。

结论

本研究表明，喷瓜果实乙醇提取物对金黄色葡萄球菌和白色念珠菌具有抗菌活性，并且在治疗由MRSA和MSSA菌株引起的感染时，青霉素与喷瓜提取物联合使用具有可能性。需要进行更广泛的研究以确定这些成分的有效成分、作用方式以及体内可能的毒性作用。