Sasmal S, Majumdar S, Gupta M, Mukherjee A, Mukherjee P K
Department of Dravyaguna (Medicinal Pharmacology), Institute of Post Graduate Ayurvedic Education and Research, Kolkata, India.
Asian Pac J Trop Biomed. 2012 Oct;2(10):782-6. doi: 10.1016/S2221-1691(12)60229-9.
To conduct a systemic evaluation of the medicinal value of seeds which include macroscopic and microscopic characterization, physiochemical evaluation, preliminary phytochemical screening and experimental antipyretic activity.
Saraca asoca seed was studied for pharmacognostical, phytochemical and other recommended methods for standardizations. Also, the acetone extract of the seeds was evaluated for acute toxicity study and antipyretic activity using Brewer's yeast induced pyrexia in Wistar rats at oral doses of 300 mg/kg and 500 mg/kg.
After phytochemical screening, the acetone extract showed the presence of saponin, tannins and flavonoids which inhibit pyrexia. The therapeutic efficacy achieved at both the dose levels of the research drug and standard drug aspirin (100 mg/kg) showed significant (P<0.01) antipyretic activity when compared to the control group. The highly significant antipyretic effect exhibited at the dose of 500 mg/kg was also found to be sustainable in nature.
The antipyretic effect of the acetone extract showed significant results in rats at the dose of 500 mg/kg after following the standard pharmacognostical and phytochemical methods.
对种子的药用价值进行系统评价，包括宏观和微观特征、理化评价、初步植物化学筛选及实验性解热活性。
采用生药学、植物化学及其他推荐的标准化方法对无忧花种子进行研究。此外，使用丙酮提取物，以300 mg/kg和500 mg/kg的口服剂量，对Wistar大鼠进行啤酒酵母诱导发热模型的急性毒性研究和解热活性评价。
植物化学筛选后，丙酮提取物显示含有抑制发热的皂苷、单宁和黄酮类化合物。与对照组相比，研究药物两个剂量水平和标准药物阿司匹林（100 mg/kg）均显示出显著（P<0.01）的解热活性。500 mg/kg剂量下表现出的高度显著解热作用在性质上也是可持续的。
按照标准生药学和植物化学方法，丙酮提取物在500 mg/kg剂量下对大鼠显示出显著的解热效果。
