油棕甲醇提取物对MCF-7和Vero细胞系的细胞毒性。
Cytotoxicity of methanol extracts of Elaeis guineensis on MCF-7 and Vero cell lines.
作者信息
Vijayarathna Soundararajan, Sasidharan Sreenivasan
机构信息
Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800, Pulau Pinang, Malaysia.
出版信息
Asian Pac J Trop Biomed. 2012 Oct;2(10):826-9. doi: 10.1016/S2221-1691(12)60237-8.
Abstract
OBJECTIVE
To investigate the cytotoxic effect of Elaeis guineensis methanol extract on MCF-7 and Vero cell.
METHODS
In vitro cytotoxicity was evaluated in by MTT assay. Cell morphological changes were observed by using light microscope.
RESULTS
The MTT assay indicated that methanol extract of the plant exhibited significant cytotoxic effects on MCF-7. Morphological alteration of the cell lines after exposure with Elaeis guineensis extract were observed under phase contrast microscope in the dose dependent manner.
CONCLUSIONS
The results suggest the probable use of the Elaeis guineensis methanol extract in preparing recipes for cancer-related ailments. Further studies on isolation of metabolites and their in vivo cytotoxicity are under investigation.
摘要
目的
研究油棕甲醇提取物对MCF-7和Vero细胞的细胞毒性作用。
方法
采用MTT法评估体外细胞毒性。使用光学显微镜观察细胞形态变化。
结果
MTT分析表明，该植物的甲醇提取物对MCF-7具有显著的细胞毒性作用。在相差显微镜下观察到，经油棕提取物处理后的细胞系形态改变呈剂量依赖性。
结论
结果表明油棕甲醇提取物可能用于制备与癌症相关疾病的配方。目前正在对代谢物的分离及其体内细胞毒性进行进一步研究。
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