尼日利亚阿利盖特胡椒、生姜和肉豆蔻多酚提取物的抗糖化、抗氧化及毒理学潜力
Antiglycation, antioxidant and toxicological potential of polyphenol extracts of alligator pepper, ginger and nutmeg from Nigeria.
作者信息
Kazeem M I, Akanji M A, Hafizur Rahman M, Choudhary M I
机构信息
Department of Biochemistry, University of Ilorin, PMB 1515, Ilorin, Nigeria ; Department of Biochemistry, Lagos State University, PMB 0001, Ojo, Lagos, Nigeria ; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.
出版信息
Asian Pac J Trop Biomed. 2012 Sep;2(9):727-32. doi: 10.1016/S2221-1691(12)60218-4.
Abstract
OBJECTIVE
To evaluate the antioxidant and antiglycation potential of polyphenols from three spices; alligator pepper, ginger and nutmeg.
METHODS
Polyphenol extracts of these spices were subjected to brine-shrimp lethality assay, phytotoxicity test, DPPH and superoxide anion radical scavenging as well as BSA-glucose antiglycation assay.
RESULTS
Results obtained showed that polyphenol extract of ginger has the highest antioxidant potential with IC50 0.075 and 0.070 mg/mL for DPPH and superoxide anion radical scavenging assay while alligator pepper displayed highest antiglycation activity with IC50 0.125 mg/mL. However, nutmeg extract exhibited weakest cytotoxic and phytotoxic potential with LD50 4359.70 and 1490 µg/mL respectively.
CONCLUSIONS
It can be concluded that the polyphenol extracts of alligator pepper, ginger and nutmeg displayed good antioxidant as well as antiglycation potential and are safe for consumption.
摘要
目的
评估三种香料（非洲豆蔻、生姜和肉豆蔻）中多酚的抗氧化和抗糖化潜力。
方法
对这些香料的多酚提取物进行卤虫致死率测定、植物毒性测试、DPPH和超氧阴离子自由基清除以及牛血清白蛋白-葡萄糖抗糖化测定。
结果
所得结果表明，生姜的多酚提取物具有最高的抗氧化潜力，在DPPH和超氧阴离子自由基清除测定中IC50分别为0.075和0.070 mg/mL，而非洲豆蔻表现出最高的抗糖化活性，IC50为0.125 mg/mL。然而，肉豆蔻提取物表现出最弱的细胞毒性和植物毒性潜力，LD50分别为4359.70和1490 µg/mL。
结论
可以得出结论，非洲豆蔻、生姜和肉豆蔻的多酚提取物具有良好的抗氧化和抗糖化潜力，食用安全。
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