Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, USA.
Org Lett. 2013 Jul 5;15(13):3342-5. doi: 10.1021/ol401377q. Epub 2013 Jun 14.
A protocol for the stereocontrolled synthesis of (E)- and (Z)-β,γ-unsaturated esters and amides is reported. 2-Chloroacetates as well as secondary and tertiary 2-chloroacetamides were successfully employed as electrophiles in the Suzuki-Miyaura cross-coupling reaction with potassium (E)- and (Z)-alkenyltrifluoroborates, affording the corresponding products in high yield.
本文报道了一种立体控制合成（E）-和（Z）-β,γ-不饱和酯和酰胺的方法。2-氯乙酸酯以及仲和叔 2-氯乙酰胺作为亲电试剂，在铃木-宫浦交叉偶联反应中与（E）-和（Z）-烯基三氟硼酸钾反应，高产率得到相应产物。
